Livache T, Bazin H, Caillat P, Roget A
CIS Bio International, DIVT, Bagnols/Cèze, France.
Biosens Bioelectron. 1998 Sep 15;13(6):629-34. doi: 10.1016/s0956-5663(98)00018-9.
We wish to show in this paper new developments and new applications of the pyrrole copolymerization process allowing the addressing of pyrrole-modified biomolecules on microelectrode arrays. Two main developments are described: the first one concerns the development of multiplexed silicon chips bearing 128 microelectrodes instead of 48 for the passive chips. The second one deals with new applications of this grafting process concerning not only DNA chips but peptide chips too. In this way, copolymerization of pyrrole peptides on the chip (leading to peptide chip) and their immunological detection is illustrated. This technology shows a high dimensional resolution and a real versatility.
我们希望在本文中展示吡咯共聚过程的新进展和新应用，该过程可用于在微电极阵列上处理吡咯修饰的生物分子。文中描述了两个主要进展：第一个进展涉及多路复用硅芯片的开发，该芯片带有128个微电极，而不是无源芯片的48个微电极。第二个进展涉及这种接枝过程的新应用，不仅涉及DNA芯片，还涉及肽芯片。通过这种方式，展示了芯片上吡咯肽的共聚（导致肽芯片）及其免疫检测。这项技术显示出高维度分辨率和真正的通用性。
