Shrestha S M, Subedi N B, Shrestha S, Maharjan K G, Tsuda F, Okamoto H
Liver Foundation Nepal, Kathmandu, Nepal.
Trop Gastroenterol. 1998 Jul-Sep;19(3):102-4.
Prevalence of hepatitis C virus (HCV) infection in Nepal was studied by assaying sera from different population groups for anti-HCV by the second generation enzyme immunoassay method and for HCV RNA by polymerase chain reaction. The anti-HCV was positive in 0.6% of 2,860 healthy adults. HCV infection was responsible for 1.3% of acute viral hepatitis. Only drug addicts (DA) are known to have a very high incidence of the infection. The number of intravenous drug abusers (IDA) in Nepal have increased considerably since 1991 when buprenorphine (tidigesic) was introduced in the local market. About 72% of the drug addicts were found to be IDA and 94% of the IDA were anti-HCV positive. It is concluded that though the prevalence of HCV infection in the community is low, and at present it accounts for only a small number of acute and chronic liver diseases, the presence of a large number of DA in the country with high incidence of HCV infection may result in the emergence of HCV as an important cause of chronic liver disease in Nepal in future.
通过采用第二代酶免疫测定法检测不同人群血清中的抗丙型肝炎病毒（HCV）以及采用聚合酶链反应检测HCV RNA，对尼泊尔丙型肝炎病毒（HCV）感染的流行情况进行了研究。在2860名健康成年人中，0.6%的人抗HCV呈阳性。HCV感染导致了1.3%的急性病毒性肝炎。已知只有吸毒者（DA）的感染发生率非常高。自1991年丁丙诺啡（替狄吉）在当地市场推出以来，尼泊尔静脉注射吸毒者（IDA）的数量大幅增加。约72%的吸毒者被发现是IDA，94%的IDA抗HCV呈阳性。研究得出结论，尽管社区中HCV感染的流行率较低，目前它仅占少数急性和慢性肝病病例，但该国存在大量HCV感染发生率高的吸毒者，未来HCV可能会成为尼泊尔慢性肝病的一个重要病因。
