Shirin T, Ahmed T, Iqbal A, Islam M, Islam M N
Department of Virology, National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh.
J Health Popul Nutr. 2000 Dec;18(3):145-50.
This cross-sectional study investigated the prevalence and risk factors of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections among 266 drug users attending a drug-addiction treatment centre in Dhaka, Bangladesh, from November 1996 to April 1997. Of the 266 addicts, 129 were injectable drug users (IDUs), and 137 were non-injectable drug users (non-IDUs). The seroprevalences of hepatitis B virus surface antigen (HBsAg), anti-HBc, anti-HBs, and anti-HCV antibodies among the IDUs were 8 (6.2%), 41 (31.8%), 15 (11.6%), and 32 (24.8%), and among the non-IDUs were 6 (4.4%), 33 (24.1%), 9 (6.6%), and 8 (5.8%) respectively. None of the drug users were positive for anti-HIV antibody. Although the prevalence of HBV infection did not significantly differ between the IDUs and the non-IDUs, the prevalence of HCV infection was significantly higher among the IDUs. Among the IDUs, the prevalence of both HBV and HCV infections was associated with sharing of needles and longer duration of injectable drugs used. The seroprevalence of HBV infection in both IDUs and non-IDUs was significantly higher among those who had a history of extramarital and premarital sex. The prevalence of HCV infection was not associated with sexual promiscuity. There was no association between the seroprevalence of HBV and HCV infections and age. Active preventive programmes focusing on educational campaigns among the youths against substance abuse should be undertaken.
这项横断面研究调查了1996年11月至1997年4月期间在孟加拉国达卡一家戒毒治疗中心接受治疗的266名吸毒者中乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）感染的患病率及危险因素。在这266名吸毒者中，129名是注射吸毒者（IDU），137名是非注射吸毒者（非IDU）。IDU中乙型肝炎病毒表面抗原（HBsAg）、抗HBc、抗HBs和抗HCV抗体的血清阳性率分别为8例（6.2%）、41例（31.8%）、15例（11.6%）和32例（24.8%），非IDU中分别为6例（4.4%）、33例（24.1%）、9例（6.6%）和8例（5.8%）。所有吸毒者的抗HIV抗体均为阴性。虽然IDU和非IDU之间HBV感染的患病率没有显著差异，但IDU中HCV感染的患病率显著更高。在IDU中，HBV和HCV感染的患病率均与共用针头及使用注射毒品的时间较长有关。有婚外和婚前性行为史的IDU和非IDU中HBV感染的血清阳性率均显著更高。HCV感染的患病率与性乱交无关。HBV和HCV感染的血清阳性率与年龄之间没有关联。应开展积极的预防项目，重点是针对青少年开展反对药物滥用的教育活动。
