Radhi J M, Ibrahiem K, al-Tweigeri T
Department of Pathology, College of Medicine, Royal University Hospital, Saskatoon, Saskatchewan, Canada.
J Clin Pathol. 1998 Aug;51(8):629-32. doi: 10.1136/jcp.51.8.629.
Three diffuse centroblastic lymphomas developed at the site of previous surgery. Two were preceded by atypical lymphoid infiltrates. Clinical data, microscopic features, and immunophenotypic studies were reviewed. All three patients presented with soft tissue masses at the site of previous surgery and metallic implants, with no evidence of lymphadenopathy, hepatosplenomegaly, or bone marrow involvement. There was no history of immunosuppression or risk factors. In two cases the initial diagnosis was of atypical lymphoid infiltrate progressing to lymphoma. Pathological examination showed a diffuse centroblastic lymphoma with an angiocentric pattern in one case. Phenotypic studies confirmed B cell origin. Soft tissue malignant lymphoma, though uncommon, can occur at the site of previous orthopaedic surgery, in particular joint replacement. Atypical lymphoid infiltrate may signal such an event.
三例弥漫性中心母细胞性淋巴瘤发生于既往手术部位。其中两例之前有非典型淋巴样浸润。回顾了临床资料、显微镜下特征及免疫表型研究。所有三名患者均在既往手术部位及金属植入物处出现软组织肿块，无淋巴结肿大、肝脾肿大或骨髓受累的证据。无免疫抑制病史或危险因素。两例最初诊断为非典型淋巴样浸润进展为淋巴瘤。病理检查显示一例为血管中心型弥漫性中心母细胞性淋巴瘤。表型研究证实为B细胞起源。软组织恶性淋巴瘤虽不常见，但可发生于既往骨科手术部位，尤其是关节置换处。非典型淋巴样浸润可能预示着这样一种情况。
