采用化学发光检测法测定萘普生。
Determination of naproxen with chemiluminescence detection.
作者信息
Campiglio A
机构信息
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
出版信息
Analyst. 1998 Jul;123(7):1571-4. doi: 10.1039/a802013b.
A rapid chemiluminescence method is described for the determination of naproxen, based on the chemiluminescence reaction with cerium(IV) in sulfuric acid medium. The optimum conditions for the chemiluminescence emission were investigated. With the integrated chemiluminescence intensity for 15 s after CeIV injection as a quantitative parameter, naproxen can be determined over the concentration range 100-1000 ng ml-1 with a detection limit of 15 ng ml-1 and with RSDs (n = 10) of 0.9% and 1.5% at levels of 1000 and 100 ng ml-1, respectively. The method was applied to the determination of naproxen in pharmaceutical preparations.
描述了一种基于在硫酸介质中与铈（IV）的化学发光反应测定萘普生的快速化学发光方法。研究了化学发光发射的最佳条件。以注入CeIV后15 s的积分化学发光强度作为定量参数，萘普生在100 - 1000 ng ml-1的浓度范围内可被测定，检测限为15 ng ml-1，在1000和100 ng ml-1水平下的相对标准偏差（n = 10）分别为0.9%和1.5%。该方法应用于药物制剂中萘普生的测定。
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