Emmerich J
Service de médecine vasculaire, hôpital Broussais, Paris.
Arch Mal Coeur Vaiss. 1998 Oct;91 Spec No 5:13-9.
Epidemiological and experimental data linking hypercholesterolaemia to atherosclerosis is well established and confirms it has a major risk factor for atherosclerosis. The fact that an increase in blood cholesterol is not necessary or obligatory for atherosclerosis to occur, means that it cannot be considered as a causal factor of the disease. On the other hand, the benefits of treatment of hypercholesterolaemia, even in mildly elevated concentrations, have been demonstrated in many randomised trials of primary and secondary prevention in high risk subjects. Thus, beyond the arguments over cholesterol being a predisposing or causal factor, these universally accepted results have added a new therapeutic arm to the cardiological arsenal.
将高胆固醇血症与动脉粥样硬化联系起来的流行病学和实验数据已得到充分证实，并确认其是动脉粥样硬化的主要危险因素。血液胆固醇升高并非动脉粥样硬化发生所必需或必然的，这意味着不能将其视为该疾病的致病因素。另一方面，在许多针对高危人群的一级和二级预防随机试验中，已证明治疗高胆固醇血症（即使是轻度升高）是有益的。因此，除了关于胆固醇是诱发因素还是致病因素的争论之外，这些普遍认可的结果为心脏病治疗手段增添了新的方法。
