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Antimicrob Agents Chemother. 1998 Dec;42(12):3309-12. doi: 10.1128/AAC.42.12.3309.
2
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Effect of proinflammatory cytokines on the interplay between roxithromycin, HMR 3647, or HMR 3004 and human polymorphonuclear neutrophils.促炎细胞因子对罗红霉素、HMR 3647或HMR 3004与人类多形核中性粒细胞相互作用的影响。
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本文引用的文献

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Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice.小鼠肺炎球菌肺部感染后细胞因子动力学及其他宿主因素
Infect Immun. 1998 Mar;66(3):912-22. doi: 10.1128/IAI.66.3.912-922.1998.
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Antibacterial activity of RU 64004 (HMR 3004), a novel ketolide derivative active against respiratory pathogens.新型酮内酯衍生物RU 64004（HMR 3004）对呼吸道病原体的抗菌活性
Antimicrob Agents Chemother. 1997 Oct;41(10):2149-58. doi: 10.1128/AAC.41.10.2149.
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Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithromycin and roxithromycin.新型酮内酯RU 64004在人中性粒细胞中的细胞蓄积：与阿奇霉素和罗红霉素的比较。
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Susceptibilities of 228 penicillin- and erythromycin-susceptible and -resistant pneumococci to RU 64004, a new ketolide, compared with susceptibilities to 16 other agents.228株对青霉素和红霉素敏感及耐药的肺炎球菌对新型酮内酯类药物RU 64004的敏感性，与对其他16种药物的敏感性比较。
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In vitro evaluation of a novel ketolide antimicrobial agent, RU-64004.新型酮内酯类抗菌剂RU-64004的体外评价
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Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry.单次口服阿奇霉素、克拉霉素和罗红霉素对通过流式细胞术体外评估的多形核白细胞功能的影响。
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HMR 3004对热灭活肺炎链球菌引起的小鼠肺部炎症的免疫调节作用

Immunomodulating effects of HMR 3004 on pulmonary inflammation caused by heat-killed Streptococcus pneumoniae in mice.

作者信息

Duong M, Simard M, Bergeron Y, Ouellet N, Côté-Richer M, Bergeron M G

机构信息

Centre de Recherche en Infectiologie, Centre Hospitalier de l'Université Laval, and Département de Microbiologie, Faculté de Médecine, Université Laval, Québec, Canada G1V 4G2.

出版信息

Antimicrob Agents Chemother. 1998 Dec;42(12):3309-12. doi: 10.1128/AAC.42.12.3309.

DOI:10.1128/AAC.42.12.3309
PMID:9835535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC106043/
Abstract

We investigated the influence of HMR 3004, a new ketolide antibiotic, on the pulmonary inflammation induced by heat-killed fluorescein isothiocyanate-labeled Streptococcus pneumoniae. HMR 3004 downregulated (P < 0.05) the pneumococcus-induced release of interleukin-6 (IL-6), IL-1beta, and nitric oxide in bronchoalveolar lavage fluid. The drug limited (P < 0.05) neutrophil recruitment to lung tissues and alveoli but did not interfere with phagocytosis. HMR 3004 totally abrogated lung edema. By reducing inflammation in addition to possessing antimicrobial properties, HMR 3004 may participate in improving the outcome of bacterial pneumonia.

摘要

我们研究了新型酮内酯类抗生素HMR 3004对热灭活的异硫氰酸荧光素标记的肺炎链球菌诱导的肺部炎症的影响。HMR 3004下调（P<0.05）了肺炎链球菌诱导的支气管肺泡灌洗液中白细胞介素-6（IL-6）、IL-1β和一氧化氮的释放。该药物限制了（P<0.05）中性粒细胞向肺组织和肺泡的募集，但不干扰吞噬作用。HMR 3004完全消除了肺水肿。通过除具有抗菌特性外还能减轻炎症，HMR 3004可能有助于改善细菌性肺炎的预后。