Sax K W, Strakowski S M
Department of Psychiatry, University of Cincinnati College of Medicine, USA.
Biol Psychiatry. 1998 Dec 1;44(11):1192-5. doi: 10.1016/s0006-3223(98)00168-1.
This study examined whether the magnitude of the behavioral response to repeated d-amphetamine administration previously demonstrated in a double-blind study in humans was associated with certain personality characteristics.
Eleven normal volunteers completed the Tridimensional Personality Questionnaire (TPQ) prior to being administered three doses of d-amphetamine (0.25 mg/kg) alternating with three doses of placebo over 6 consecutive days. Behavioral measures included eye-blink rates as well as ratings of elevated mood, increased motor activity/energy, and increased speech. These variables were assessed once prior to dosing, then hourly for 5 hours.
A greater magnitude of change in elevated mood over the three amphetamine doses significantly correlated with ratings of the Novelty Seeking on the TPQ.
These results suggest that similar to findings in animal models, there are certain intrinsic behavioral characteristics that are associated with amphetamine sensitivity in humans.
本研究探讨了在一项针对人类的双盲研究中先前证明的重复给予右旋苯丙胺后行为反应的程度是否与某些人格特征相关。
11名正常志愿者在连续6天内接受三剂右旋苯丙胺（0.25mg/kg）和三剂安慰剂交替给药之前，完成了三维人格问卷（TPQ）。行为测量包括眨眼率以及情绪高涨、运动活动/精力增加和言语增多的评分。这些变量在给药前评估一次，然后每小时评估5小时。
在三剂苯丙胺给药期间，情绪高涨的变化幅度更大与TPQ上的新奇寻求评分显著相关。
这些结果表明，与动物模型中的发现相似，人类中存在某些与苯丙胺敏感性相关的内在行为特征。
