Beretta-Piccoli C, Weidmann P, De Châtel R, Reubi F
Am J Med. 1976 Nov;61(5):739-47. doi: 10.1016/0002-9343(76)90155-8.
Interrelations among blood pressure, exchangeable sodium, blood volume and plasma renin activity were studied in 40 normal subjects and in 40 patients with early stage kidney disease (mean plasma creatinine, 2 mg/100 ml). Findings in eight normotensive patients did not differ significantly from those in normal subjects. However, 32 hypertensive patients showed increases (p less than 0.05) in mean exchangeable sodium and in the products of the logarithm of plasma renin activity and exchangeable sodium or blood volume. In normal subjects, blood pressure did not correlate with any of the parameters measured. In the patients, it correlated significantly (p less than 0.05) with duration of hypertension (r = 0.70), exchangeable sodium (r = 0.34) and with sodium-renin (r = 0.38) or volume-renin (r = 0.30) products, but not with blood volume or circulating renin individually. Multiple regression analysis with blood pressure as a dependent variable, and duration of hypertension and the sodium-renin or volume-renin products as independent variables, revealed correlation coefficients of 0.77 and 0.76, respectively. These findings suggest that hypertension accompanying early stage kidney disease may depend at least partly on subtle abnormalities in the sodium volume-renin feedback mechanism as well as on a factor related to the duration of preexisting hypertension.
对40名正常受试者和40名早期肾病患者（平均血浆肌酐为2mg/100ml）的血压、可交换钠、血容量和血浆肾素活性之间的相互关系进行了研究。8名血压正常的患者的研究结果与正常受试者的结果无显著差异。然而，32名高血压患者的平均可交换钠以及血浆肾素活性与可交换钠或血容量的乘积增加（p<0.05）。在正常受试者中，血压与所测的任何参数均无相关性。在患者中，血压与高血压病程（r=0.70）、可交换钠（r=0.34）以及钠-肾素（r=0.38）或容量-肾素（r=0.30）乘积显著相关（p<0.05），但与血容量或循环肾素个体无相关性。以血压为因变量，高血压病程以及钠-肾素或容量-肾素乘积为自变量进行多元回归分析，相关系数分别为0.77和0.76。这些发现提示，早期肾病伴发的高血压可能至少部分取决于钠容量-肾素反馈机制的细微异常以及与既往高血压病程相关的一个因素。
