Des Jarlais D C, Perlis T, Friedman S R, Deren S, Chapman T, Sotheran J L, Tortu S, Beardsley M, Paone D, Torian L V, Beatrice S T, DeBernardo E, Monterroso E, Marmor M
Chemical Dependency Institute, Beth Israel Medical Center, New York, NY 10003, USA.
Am J Public Health. 1998 Dec;88(12):1801-6. doi: 10.2105/ajph.88.12.1801.
This study assessed recent trends in HIV seroprevalence among injecting drug users in New York City.
We analyzed temporal trends in HIV seroprevalence from 1991 through 1996 in 5 studies of injecting drug users recruited from a detoxification program, a methadone maintenance program, research storefronts in the Lower East Side and Harlem areas, and a citywide network of sexually transmitted disease clinics. A total of 11,334 serum samples were tested.
From 1991 through 1996, HIV seroprevalence declined substantially among subjects in all 5 studies: from 53% to 36% in the detoxification program, from 45% to 29% in the methadone program, from 44% to 22% at the Lower East Side storefront, from 48% to 21% at the Harlem storefront, and from 30% to 21% in the sexually transmitted disease clinics (all P < .002 by chi 2 tests for trend).
The reductions in HIV seroprevalence seen among injecting drug users in New York City from 1991 through 1996 indicate a new phase in this large HIV epidemic. Potential explanatory factors include the loss of HIV-seropositive individuals through disability and death and lower rates of risk behavior leading to low HIV incidence.
本研究评估了纽约市注射吸毒者中艾滋病毒血清流行率的近期趋势。
我们分析了1991年至1996年期间从戒毒项目、美沙酮维持治疗项目、下东区和哈莱姆区的研究店面以及全市性传播疾病诊所网络招募的5项注射吸毒者研究中艾滋病毒血清流行率的时间趋势。共检测了11334份血清样本。
1991年至1996年期间，所有5项研究中的受试者艾滋病毒血清流行率均大幅下降：戒毒项目中从53%降至36%，美沙酮项目中从45%降至29%，下东区店面从44%降至22%，哈莱姆店面从48%降至21%，性传播疾病诊所从30%降至21%（趋势的卡方检验所有P<.002）。
1991年至1996年纽约市注射吸毒者中艾滋病毒血清流行率的下降表明了这一大型艾滋病毒疫情进入了一个新阶段。潜在的解释因素包括因残疾和死亡导致艾滋病毒血清阳性个体减少以及导致艾滋病毒低发病率的风险行为发生率降低。
