Ruben F L, Streiff E J, Neal M, Michaels R H
Am J Public Health. 1976 Nov;66(11):1096-8. doi: 10.2105/ajph.66.11.1096.
Twenty-seven cases of Reye's syndrome (RS) were admitted over a 19-month period to one urban hospital. All lived in a suburban or rural location and 23 cases occurred during two influenza outbreaks. Two to three months following the last cases of RS, 24 families of RS cases and 21 control families representing neighbors or friends were interviewed for factors which could predispose to RS. Children with RS had an illness immediately preceding the onset of RS more frequently than did controls (p less than .001). No other clinical, familial, or environmental factors distinguished RS children and families from controls. Water samples, collected during the interviews, from 34 homes showed no potential toxins. The geographic pattern of RS cases with localization exclusively to rural areas suggests that an as yet unidentified environmental factor may be related to the development of RS.
在19个月的时间里，一家城市医院收治了27例瑞氏综合征（RS）患者。所有患者均居住在郊区或农村地区，其中23例发生在两次流感暴发期间。在最后一例RS病例出现两到三个月后，对24个RS病例家庭和21个代表邻居或朋友的对照家庭进行了访谈，以了解可能易患RS的因素。与对照组相比，RS患儿在RS发病前更频繁地患有前驱疾病（p<0.001）。没有其他临床、家族或环境因素能将RS患儿及其家庭与对照组区分开来。在访谈期间从34户家庭采集的水样中未发现潜在毒素。RS病例仅局限于农村地区的地理分布模式表明，一种尚未确定的环境因素可能与RS的发生有关。
