Ramesh G, Das U N
Division of Internal Medicine, Clinical Immunology and Biochemistry, L.V. Prasad Eye Institute, Hyderabad, India.
Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):155-61. doi: 10.1016/s0952-3278(98)90056-4.
The effect of fish oil (FO, given in the form of MaxEPA) rich in n-3 fatty acids and evening primrose oil (EPO) rich in n-6 fatty acids on two-stage skin carcinogenesis in mice was studied. Both FO and EPO inhibited the papilloma formation to a significant degree only during the promotion stage which was associated with an increase in lipid peroxidation. Both FO and EPO inhibited the binding of benzo(a)-pyrene to skin cell DNA suggesting that this could be one of the mechanism(s) by which these oils could be preventing papilloma development. Neither EPO nor FO influenced epidermal cell proliferation. In the FO group, LA (linoleic acid), AA (arachidonic acid) and DHA (docosahexaenoic acid) were increased, whereas in the EPO group a significant increase in the AA content was noted. No specific changes in the fatty acid pattern were observed in any of the groups that could be attributed to the papilloma incidence. These results suggest that FO and EPO can influence papilloma formation which can be attributed, at least in part, to their ability to prevent benzo(a)pyrene binding to DNA and to an increase the lipid peroxidation process.
研究了富含n-3脂肪酸的鱼油（以MaxEPA形式给予）和富含n-6脂肪酸的月见草油（EPO）对小鼠两阶段皮肤致癌作用的影响。鱼油和月见草油仅在与脂质过氧化增加相关的促进阶段对乳头瘤形成有显著抑制作用。鱼油和月见草油均抑制苯并(a)芘与皮肤细胞DNA的结合，表明这可能是这些油预防乳头瘤发展的机制之一。月见草油和鱼油均未影响表皮细胞增殖。在鱼油组中，亚油酸（LA）、花生四烯酸（AA）和二十二碳六烯酸（DHA）增加，而在月见草油组中，AA含量显著增加。在任何一组中均未观察到可归因于乳头瘤发生率的脂肪酸模式的特异性变化。这些结果表明，鱼油和月见草油可影响乳头瘤形成，这至少部分可归因于它们防止苯并(a)芘与DNA结合以及增加脂质过氧化过程的能力。
