Dogrukol-Ak D, Zaimoglu V, Tunçel M
University of Anadolu, Faculty of Pharmacy, Department of Analytical Chemistry, 26470 Eskisehir, Turkey.
Eur J Pharm Sci. 1999 Feb;7(3):215-20. doi: 10.1016/s0928-0987(98)00021-9.
The voltammetric behaviors of trazodone using a platinum electrode in stationary or rotating conditions and its determination in tablets by DP rotating electrodes are described in this study. The experiments were conducted in the supporting electrolyte consisting of 0.2 M KCl and 0.2 M acetate or phosphate buffer. No adsorption was observed at +300 mV. The factor affecting the voltammetric current was diffusional in the range of 200-2000 rpm for rotating, and 2-10 mV potential rate for stationary conditions; and the calibration dependence was linear between 1x10-5-5x10-5 M trazodone solutions. The detection limit was found to be 2.5x10-6 M (sb=5.03, n=5) for stationary and 1.7x10-6 M (sb=2.12, n=5) for rotating electode assuming a signal to noise ratio of 3. According to the statistical evaluations, acceptable results were obtained at the 95% probability level. Therefore, the proposed method is practicable, sensitive and accurate for the analysis of trazodone preparations in quality control laboratories.
本研究描述了曲唑酮在铂电极上于静止或旋转条件下的伏安行为及其通过微分脉冲旋转电极法在片剂中的测定。实验在由0.2 M氯化钾和0.2 M醋酸盐或磷酸盐缓冲液组成的支持电解质中进行。在 +300 mV 时未观察到吸附现象。对于旋转电极，在200 - 2000 rpm范围内影响伏安电流的因素是扩散，对于静止条件，电位扫描速率为2 - 10 mV；在1×10⁻⁵ - 5×10⁻⁵ M曲唑酮溶液之间校准依赖性呈线性。假设信噪比为3，静止电极的检测限为2.5×10⁻⁶ M（sb = 5.03，n = 5），旋转电极的检测限为1.7×10⁻⁶ M（sb = 2.12，n = 5）。根据统计评估，在95%概率水平下获得了可接受的结果。因此，所提出的方法对于质量控制实验室中曲唑酮制剂的分析是可行、灵敏且准确的。
