Komaromy-Hiller G, Swallow K L, Moulton L
Department of Pathology, University of Utah School of Medicine, Salt Lake City 84132, USA.
Ann Clin Lab Sci. 1998 Nov-Dec;28(6):347-53.
Urinary electrolytes are invaluable in the differential diagnosis and treatment of certain acid-base diseases. We have evaluated the accuracy and precision of three different automated chemistry analyzers and a chloridometer (Corning 925 Chloridometer, Hitachi 717 and 917 and Vitros 950) for chloride, sodium and potassium using standard solutions. Data indicate that the ISE modules on the Hitachi 717 and 917 analyzers measure sodium and potassium accurately and precisely throughout the studied concentration range. The Vitros 950 system had the poorest precision and accuracy performance at the low levels of sodium and potassium. The chloride ion-selective membranes on the Hitachi analyzers seriously overestimate the chloride concentration at all levels. The manual dilution method on the Vitros 950 analyzer for chloride measurements showed good precision and accuracy only at the higher chloride levels. For chloride determination the chloridometer displayed the best accuracy with good precision. We recommend that laboratories use chloridometers for the measurement of urinary chloride, and that the CAP include low chloride samples in their proficiency testing program for urine chloride.
尿电解质在某些酸碱疾病的鉴别诊断和治疗中具有重要价值。我们使用标准溶液评估了三种不同的自动化学分析仪和一台氯化物测定仪（康宁925氯化物测定仪、日立717和917以及维特罗斯950）测定氯化物、钠和钾的准确性和精密度。数据表明，日立717和917分析仪上的离子选择性电极模块在整个研究浓度范围内能够准确、精确地测定钠和钾。在钠和钾的低浓度水平下，维特罗斯950系统的精密度和准确性表现最差。日立分析仪上的氯离子选择性膜在所有水平上都严重高估了氯化物浓度。维特罗斯950分析仪上用于氯化物测量的手动稀释法仅在较高氯化物水平下显示出良好的精密度和准确性。对于氯化物测定，氯化物测定仪显示出最佳的准确性和良好的精密度。我们建议实验室使用氯化物测定仪来测量尿氯化物，并且美国病理学家协会在其尿氯化物能力验证计划中应纳入低氯化物样本。
