Attwood T K, Flower D R, Lewis A P, Mabey J E, Morgan S R, Scordis P, Selley J N, Wright W
School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK.
Nucleic Acids Res. 1999 Jan 1;27(1):220-5. doi: 10.1093/nar/27.1.220.
PRINTS is a diagnostic collection of protein fingerprints. Fingerprints exploit groups of motifs to build characteristic family signatures, offering improved diagnostic reliability over single-motif approaches by virtue of the mutual context provided by motif neighbours. Around 1000 fingerprints have now been created and stored in PRINTS. The September 1998 release (version 20.0), encodes approximately 5700 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. The database is accessible via the DbBrowser Web Server at http://www.biochem.ucl.ac.uk/bsm/dbbrowser /. In addition to supporting its continued growth, recent enhancements to the resource include a BLAST server, and more efficient fingerprint search software, with improved statistics for estimating the reliability of retrieved matches. Current efforts are focused on the design of more automated methods for database maintenance; implementation of an object-relational schema for efficient data management; and integration with PROSITE, profiles, Pfam and ProDom, as part of the international InterPro project, which aims to unify protein pattern databases and offer improved tools for genome analysis.
PRINTS是一个蛋白质指纹图谱的诊断集合。指纹图谱利用基序组构建特征性的家族签名，借助基序相邻序列提供的相互关联的背景信息，比单基序方法具有更高的诊断可靠性。目前已创建了约1000个指纹图谱并存储在PRINTS中。1998年9月发布的版本（20.0版）编码了大约5700个基序，涵盖了一系列球状蛋白和膜蛋白、模块化多肽等。该数据库可通过网址为http://www.biochem.ucl.ac.uk/bsm/dbbrowser /的DbBrowser网络服务器访问。除了支持其持续增长外，该资源最近的改进包括一个BLAST服务器和更高效的指纹搜索软件，以及用于估计检索到的匹配项可靠性的改进统计数据。当前的工作重点是设计更自动化的数据库维护方法；实施用于高效数据管理的对象关系模式；以及作为国际InterPro项目的一部分，与PROSITE、轮廓文件、Pfam和ProDom进行整合，该项目旨在统一蛋白质模式数据库并提供改进的基因组分析工具。
