Attwood T K, Blythe M J, Flower D R, Gaulton A, Mabey J E, Maudling N, McGregor L, Mitchell A L, Moulton G, Paine K, Scordis P
School of Biological Sciences, The University of Manchester, Manchester M13 9PT, UK.
Nucleic Acids Res. 2002 Jan 1;30(1):239-41. doi: 10.1093/nar/30.1.239.
The PRINTS database houses a collection of protein fingerprints. These may be used to make family and tentative functional assignments for uncharacterised sequences. The September 2001 release (version 32.0) includes 1600 fingerprints, encoding approximately 10 000 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. In addition to its continued steady growth, we report here its use as a source of annotation in the InterPro resource, and the use of its relational cousin, PRINTS-S, to model relationships between families, including those beyond the reach of conventional sequence analysis approaches. The database is accessible for BLAST, fingerprint and text searches at http://www.bioinf.man.ac.uk/dbbrowser/PRINTS/.
PRINTS数据库收录了一系列蛋白质指纹图谱。这些指纹图谱可用于对未表征序列进行家族分类和初步功能分配。2001年9月发布的版本(32.0版)包含1600个指纹图谱,编码约10000个基序,涵盖了一系列球状蛋白和膜蛋白、模块化多肽等。除了持续稳定增长外,我们在此报告它作为InterPro资源注释来源的用途,以及使用其相关的PRINTS-S来构建家族之间的关系模型,包括那些传统序列分析方法无法触及的关系。可通过http://www.bioinf.man.ac.uk/dbbrowser/PRINTS/对该数据库进行BLAST、指纹图谱和文本搜索。