头孢克洛在犬血清、组织间液、胆汁和尿液中的浓度关系。
Concentration relationships of cefaclor in serum, interstitial fluid, bile, and urine of dogs.
作者信息
Waterman N G, Scharfenberger L F
出版信息
Antimicrob Agents Chemother. 1978 Oct;14(4):614-6. doi: 10.1128/AAC.14.4.614.
Abstract
The concentrations of cefaclor in the serum, urine, bile, and tissue fluids of the abdominal wall, kidney, and liver of dogs were compared over a 4-h period after oral administration of a single dose of this drug. The concentration of cefaclor in the soft-tissue interstitial fluid peaked 2 h after administration, thereby demonstrating a diffusion rate similar to those of other cephalosporins. Both urine and bile concentrations greatly exceeded the serum levels, whereas none of the tissue fluid concentrations were greater than the serum concentrations at the times of measurement.
摘要
在给犬单次口服该药物后4小时内，比较了头孢克洛在犬的血清、尿液、胆汁以及腹壁、肾脏和肝脏组织液中的浓度。头孢克洛在软组织间质液中的浓度在给药后2小时达到峰值，这表明其扩散速率与其他头孢菌素相似。尿液和胆汁中的浓度均大大超过血清水平，而在测量时，所有组织液中的浓度均未高于血清浓度。
相似文献
1
Concentration relationships of cefaclor in serum, interstitial fluid, bile, and urine of dogs.头孢克洛在犬血清、组织间液、胆汁和尿液中的浓度关系。
Antimicrob Agents Chemother. 1978 Oct;14(4):614-6. doi: 10.1128/AAC.14.4.614.
2
Concentration of cefamandole in serum interstitial fluid, bile, and urine.头孢孟多在血清、组织间液、胆汁及尿液中的浓度。
Antimicrob Agents Chemother. 1976 Oct;10(4):733-5. doi: 10.1128/AAC.10.4.733.
3
The pharmacokinetics of the oral cephalosporins cefaclor, cephradine and cephalexin.
Int J Clin Pharmacol Biopharm. 1979 Sep;17(9):397-400.
4
Protein binding and concentrations of cephaloridine and cefazolin in serum and interstitial fluid of dogs.
J Infect Dis. 1976 Jun;133(6):642-7. doi: 10.1093/infdis/133.6.642.
5
Pharmacologic studies with cefaclor, a new oral cephalosporin.
J Clin Pharmacol. 1978 Apr;18(4):174-9. doi: 10.1002/j.1552-4604.1978.tb01590.x.
6
Absorption, distribution and excretion of SCE-963, a new broad-spectrum cephalosporin, in mice, rats, rabbits and dogs.新型广谱头孢菌素SCE - 963在小鼠、大鼠、兔子和狗体内的吸收、分布及排泄情况。
J Antibiot (Tokyo). 1978 Dec;31(12):1272-82. doi: 10.7164/antibiotics.31.1272.
7
Pharmacokinetics of FK027 in rats and dogs.FK027在大鼠和犬体内的药代动力学。
J Antibiot (Tokyo). 1985 Apr;38(4):496-504. doi: 10.7164/antibiotics.38.496.
8
Penetration of cefaclor into the interstitial space fluid of skeletal muscle and lung tissue in rats.
Pharm Res. 2001 Sep;18(9):1310-4. doi: 10.1023/a:1013042128791.
9
High-performance liquid chromatographic determination of loracarbef, a potential metabolite, cefaclor and cephalexin in human plasma, serum and urine.
J Chromatogr. 1991 Jun 14;567(1):129-39. doi: 10.1016/0378-4347(91)80317-6.
10
Metabolism of (14C) cefaclor, a cephalosporin antibiotic, in three species of laboratory animals.头孢克洛（一种头孢菌素类抗生素）在三种实验动物体内的代谢情况，其中头孢克洛用（14C）标记 。
Antimicrob Agents Chemother. 1976 Oct;10(4):630-8. doi: 10.1128/AAC.10.4.630.
引用本文的文献
1
Interstitial concentration of antibiotics and their significance for an adequate dosage.
Infection. 1980;Suppl 1:39-44. doi: 10.1007/BF01644934.
2
[Comparative study of cefaclor versus amoxicillin in urinary tract infections (author's transl)].
Infection. 1979;7 Suppl 6:617-21. doi: 10.1007/BF01659750.
3
[In vitro activity of cefaclor (author's transl)].头孢克洛的体外活性（作者译）
Infection. 1979;7 Suppl 6:518-26. doi: 10.1007/BF01659726.
本文引用的文献
1
Pathophysiology of tissue fluid.组织液的病理生理学
Proc R Soc Med. 1972 Aug;65(8):715-9. doi: 10.1177/003591577206500822.
2
Interstitial fluid and serum antibiotic concentrations.组织液和血清抗生素浓度。
Arch Surg. 1972 Aug;105(2):192-6. doi: 10.1001/archsurg.1972.04180080046008.
3
Concentration of antibacterial agents in interstitial tissue fluid.抗菌剂在组织间液中的浓度。
Br Med J. 1973 Mar 10;1(5853):569-73. doi: 10.1136/bmj.1.5853.569.
4
Concentration of selected intravenously administered antibiotics in experimental surgical wounds.实验性手术伤口中选定静脉注射抗生素的浓度。
J Trauma. 1973 May;13(5):423-34. doi: 10.1097/00005373-197305000-00004.
5
Antibiotic concentrations in hepatic interstitial and wound fluid.
Surg Gynecol Obstet. 1976 Feb;142(2):235-8.
6
Renal interstitial fluid, urine, and serum antibiotic concentration.
Surg Forum. 1975;26:589-91.
7
Concentration of antibiotics in renal interstitial fluid: an experimental model.
Urol Res. 1975 Dec 30;3(4):165-7. doi: 10.1007/BF00261952.
8
Metabolism of (14C) cefaclor, a cephalosporin antibiotic, in three species of laboratory animals.头孢克洛（一种头孢菌素类抗生素）在三种实验动物体内的代谢情况，其中头孢克洛用（14C）标记 。
Antimicrob Agents Chemother. 1976 Oct;10(4):630-8. doi: 10.1128/AAC.10.4.630.
9
Protein binding and concentrations of cephaloridine and cefazolin in serum and interstitial fluid of dogs.
J Infect Dis. 1976 Jun;133(6):642-7. doi: 10.1093/infdis/133.6.642.
10
Comparison of in vitro antibacterial activity of three oral cephalosporins: cefaclor, cephalexin, and cephradine.三种口服头孢菌素（头孢克洛、头孢氨苄和头孢拉定）的体外抗菌活性比较
Antimicrob Agents Chemother. 1977 Nov;12(5):591-6. doi: 10.1128/AAC.12.5.591.
Zotero 插件