头孢克洛在正常受试者和慢性肾衰竭患者中的药代动力学。
Pharmacokinetics of cefaclor in normal subjects and patients with chronic renal failure.
作者信息
Bloch R, Szwed J J, Sloan R S, Luft F C
出版信息
Antimicrob Agents Chemother. 1977 Dec;12(6):730-2. doi: 10.1128/AAC.12.6.730.
Abstract
We studied the pharmacokinetics of cefaclor, a new cephalosporin antibiotic, in normal subjects and subjects with chronic renal failure. Cefaclor was largely, but not entirely, eliminated by the kidneys. The cefaclor half-life in normal subjects was 40 to 60 min; in subjects with essentially no renal function, it increased to 3 h. In normal subjects, 50 to 70% of a 250-mg dose was excreted in the urine within 8 h. The linear relationship between the elimination constant and creatinine clearance allowed the construction of a useful dosage modification nomogram.
摘要
我们研究了新型头孢菌素抗生素头孢克洛在正常受试者和慢性肾功能衰竭受试者中的药代动力学。头孢克洛大部分（但并非全部）经肾脏消除。正常受试者中头孢克洛的半衰期为40至60分钟；在基本无肾功能的受试者中，半衰期延长至3小时。在正常受试者中，250毫克剂量的头孢克洛在8小时内50%至70%经尿液排泄。消除常数与肌酐清除率之间的线性关系有助于构建实用的剂量调整列线图。
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本文引用的文献
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2
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Antimicrob Agents Chemother. 1975 Jul;8(1):91-4. doi: 10.1128/AAC.8.1.91.
3
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4
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Am J Med. 1977 Apr;62(4):461-5. doi: 10.1016/0002-9343(77)90397-7.
5
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