Rau B, Hünerbein M, Barth C, Schlag P M
Robert-Rössle Klinik am Max-Delbrück-Centrum für Molekulare Medizin, Abteilung für Chirurgie und Chirurgische Onkologie, Humboldt Universität zu Berlin.
Zentralbl Chir. 1998;123(10):1125-8.
The purpose of this study was to evaluate the impact of thoracoscopy on staging and therapy of peripheral pulmonary nodules in patients with a cancer history.
Videothoracoscopy (VATS) was performed in patients presenting peripheral pulmonary nodules (< 3cm) in CT-scan. 65 patients (63%) presented less than 3 nodules and 39 patients (37%) had multiple lesions in the lungs. History revealed a primary gastro-intestinal cancer in 35 patients (34%), a sarcoma in 26 patients (25%), breast cancer in 13 patients (13%) and miscellaneous primary cancer in 22 patients (21%). VATS was performed under general anesthesia using a standard equipment (Olympus). Double lumen endotracheal intubation was carried out. Thoracoscopic pulmonary resection was accomplished with endoscopic stapler (Autosuture Multi-Fire Endo GIA 30). The specimens were removed in a retrieval bag and a tube was inserted into the thoracic cavity.
In 24 patients (23%) conversion to thoracotomy was performed, because of adhesions (n = 12), technical reasons (n = 8), no tumor detectable (n = 4). Thoracoscopic wedge resection for coin lesions was performed in 61 of the 80 patients (76%). Three patients underwent decortication and in 16 patients biopsy was sufficient for therapeutical considerations. Additional informations in comparison to conventional diagnostic were found in 39 patients (49%). The treatment regimen altered in 32 patients (40%).
In this study VATS proved to be a sensitive technique for staging of pulmonary coin lesions. Additional informations were achieved in 49% and therapeutic strategy was changed in 40% of the patients due to the distant spread of malignancy or detection of benign lesions obtained by thoracoscopic staging.
本研究的目的是评估胸腔镜检查对有癌症病史患者周围型肺结节分期及治疗的影响。
对CT扫描显示有周围型肺结节(<3cm)的患者进行电视胸腔镜手术(VATS)。65例患者(63%)有少于3个结节,39例患者(37%)肺部有多个病灶。病史显示,35例患者(34%)有原发性胃肠道癌,26例患者(25%)有肉瘤,13例患者(13%)有乳腺癌,22例患者(21%)有其他原发性癌症。VATS在全身麻醉下使用标准设备(奥林巴斯)进行。进行双腔气管插管。使用内镜吻合器(自动缝合多连发内镜切割吻合器GIA 30)完成胸腔镜肺切除术。标本装在取物袋中取出,并在胸腔内插入一根引流管。
24例患者(23%)因粘连(n = 12)、技术原因(n = 8)、未检测到肿瘤(n = 4)而转为开胸手术。80例患者中有61例(76%)因硬币样病灶接受了胸腔镜楔形切除术。3例患者进行了剥脱术,16例患者的活检结果足以用于治疗考量。与传统诊断相比,39例患者(49%)获得了更多信息。32例患者(40%)的治疗方案发生了改变。
在本研究中,VATS被证明是一种用于肺部硬币样病灶分期的敏感技术。由于恶性肿瘤远处转移或通过胸腔镜分期发现良性病灶,49%的患者获得了更多信息,40%的患者治疗策略发生了改变。