Lass A, Ellenbogen A, Croucher C, Trew G, Margara R, Becattini C, Winston R M
Institute of Obstetrics and Gynecology, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
Fertil Steril. 1998 Dec;70(6):1035-8. doi: 10.1016/s0015-0282(98)00357-4.
To investigate the effect of salpingectomy on the response of each ovary in patients undergoing an IVF-ET treatment cycle and to compare the results with those of patients who had not had surgery and were undergoing IVF-ET during the same period.
A prospective study.
Tertiary referral academic IVF unit.
PATIENT(S): Twenty-nine ET cycles were evaluated in 29 patients who previously had undergone unilateral salpingectomy because of ectopic pregnancy (study group). Seventy-three patients with unexplained or male factor infertility served as controls.
INTERVENTION(S): Ovulation induction and IVF-ET.
MAIN OUTCOME MEASURE(S): In the study group, mean ovarian volume, number of follicles, and number of oocytes recovered from each ovary were assessed and compared. The overall results, cycle characteristics, and pregnancy rates of the two groups were compared.
RESULT(S): Among the patients who had undergone salpingectomy, significantly fewer follicles developed and consequently fewer oocytes were retrieved from the ovary on the operated side (4.4 versus 8.2 follicles and 3.8 versus 6.0 oocytes). There were no differences in the total numbers of follicles and oocytes recovered from both ovaries, the cycle characteristics, or the pregnancy rates between study and control groups.
CONCLUSION(S): Salpingectomy has no detrimental effect on the total ovarian performance during IVF-ET treatment or on the outcome of IVF-ET. However, the ipsilateral ovary could be adversely affected. This could be detrimental in selected patients undergoing IVF-ET, in whom the second ovary already is compromised or missing.
探讨输卵管切除术对接受体外受精-胚胎移植（IVF-ET）治疗周期患者每个卵巢反应的影响，并将结果与同期未接受手术而进行IVF-ET的患者进行比较。
一项前瞻性研究。
三级转诊学术性IVF中心。
对29例因异位妊娠先前接受过单侧输卵管切除术的患者的29个ET周期进行了评估（研究组）。73例不明原因或男性因素不孕的患者作为对照组。
促排卵及IVF-ET。
在研究组中，评估并比较每个卵巢的平均体积、卵泡数量及回收的卵母细胞数量。比较两组的总体结果、周期特征及妊娠率。
在接受输卵管切除术的患者中，手术侧卵巢发育的卵泡明显减少，因此回收的卵母细胞也较少（4.4个对8.2个卵泡，3.8个对6.0个卵母细胞）。研究组和对照组从双侧卵巢回收的卵泡和卵母细胞总数、周期特征或妊娠率均无差异。
输卵管切除术对IVF-ET治疗期间的总体卵巢功能或IVF-ET结局无不利影响。然而，同侧卵巢可能会受到不利影响。这对于某些接受IVF-ET的患者可能是有害的，这些患者的第二个卵巢已经受损或缺失。
