Cheng T J, Wong R H, Lin Y P, Hwang Y H, Horng J J, Wang J D
Graduate Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.
Occup Environ Med. 1998 Aug;55(8):573-6. doi: 10.1136/oem.55.8.573.
Risk factors for increased blood lead concentration (BPb) has been investigated. However, the effect of sibship and Chinese herbal medicine on BPb has not been systematically studied. In this study BPb data from voluntary testing was used to determine if Chinese herbal medicine and sibship were associated with BPb.
319 children aged 1-7 were tested for BPb. Meanwhile, parents were interviewed to obtain information including consumption of Chinese herbal medicine, living environment, lifestyle, and sibship of the children tested.
The mean (SD) BPb of 319 preschool children was 4.4 (2.4) micrograms/dl. The consumption of Ba-baw-san (a Chinese herbal medicine) was significantly associated with increased BPb in children (p = 0.038). Further multivariate regression analysis of BPb in 50 pairs of siblings showed the factors of being brothers explained 75% of variation for BPb, and being sisters and brother-sister explained 51% and 41% of variation respectively.
Chinese herbal medicine and children's play patterns within the family expressed in different types of sibship are the main determinants of low concentrations of BPb in preschool children of Taiwan.
已对血铅浓度（BPb）升高的风险因素进行了调查。然而，同胞关系和中草药对BPb的影响尚未得到系统研究。在本研究中，使用自愿检测的BPb数据来确定中草药和同胞关系是否与BPb相关。
对319名1至7岁儿童进行了BPb检测。同时，对家长进行访谈以获取相关信息，包括中草药的服用情况、生活环境、生活方式以及受试儿童的同胞关系。
319名学龄前儿童的平均（标准差）BPb为4.4（2.4）微克/分升。服用八宝塔散（一种中草药）与儿童BPb升高显著相关（p = 0.038）。对50对兄弟姐妹的BPb进行的进一步多变量回归分析表明，兄弟因素解释了BPb变异的75%，姐妹因素和兄妹因素分别解释了51%和41%的变异。
中草药以及家庭中不同同胞关系所体现的儿童玩耍模式是台湾学龄前儿童低浓度BPb的主要决定因素。
