Ihara N, Akagi R, Ejiri K, Kudo T, Furuyama K, Fujita H
Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
FEBS Lett. 1998 Nov 13;439(1-2):163-7. doi: 10.1016/s0014-5793(98)01324-6.
Transcription levels of the non-specific delta-aminolevulinate synthase (ALAS-N) and heme oxygenase-1 (HO-1) in the placenta at the terminal stage of pregnancy were comparable to those in the female adult liver and in the spleen, respectively. Immunohistochemical studies demonstrated that both enzymes were exclusively expressed in the trophoblast. During gestation, transcript of ALAS-N slightly increased, while HO-1 mRNA significantly decreased. Induced acute fetal hypoxia resulted in an increase in ALAS-N mRNA and in a decrease in HO-1 mRNA. These findings indicate that placental heme metabolism is influenced by the oxygen supply.
妊娠末期胎盘非特异性δ-氨基-γ-酮戊酸合酶（ALAS-N）和血红素加氧酶-1（HO-1）的转录水平分别与成年雌性肝脏和脾脏中的相当。免疫组织化学研究表明，这两种酶仅在滋养层细胞中表达。在妊娠期，ALAS-N的转录略有增加，而HO-1 mRNA显著减少。诱导的急性胎儿缺氧导致ALAS-N mRNA增加和HO-1 mRNA减少。这些发现表明胎盘血红素代谢受氧气供应的影响。
