Coccagna G, di Donato G, Verucchi P, Cirignotta F, Mantovani M, Lugaresi E
Arch Neurol. 1976 Nov;33(11):769-76. doi: 10.1001/archneur.1976.00500110037007.
We describe a syndrome characterized by acquired micrognathia, hypersomnia, and periodic apneas during sleep. Six patients affected with the syndrome underwent nocturnal and diurnal polygraphic recordings that demonstrated that during sleep there is an uninterrupted succession of apneas, primarily the obstructive type, analogous to those observed in Pickwickian syndrome. Simultaneous recording of pulmonary and systemic arterial pressure during sleep and repeated blood gas analyses have shown that as soon as the apneas appear there is a decisive increase in pulmonary and systemic pressure and serious alveolar hypoventilation. The hemodynamic and ventilatory changes are even more intense during rapid eye movement sleep. Tracheostomy, performed on five of our patients, is the only treatment producing complete clinical remission of the syndrome.
我们描述了一种以获得性小颌畸形、嗜睡和睡眠期间周期性呼吸暂停为特征的综合征。六名患有该综合征的患者进行了夜间和日间多导睡眠图记录，结果表明睡眠期间存在不间断的呼吸暂停序列，主要是阻塞性类型，类似于在匹克威克综合征中观察到的情况。睡眠期间同时记录肺和体动脉压以及重复进行血气分析表明，一旦出现呼吸暂停，肺和体循环压力会显著升高，同时伴有严重的肺泡通气不足。快速眼动睡眠期间的血流动力学和通气变化更为强烈。我们的五名患者接受了气管切开术，这是唯一能使该综合征临床完全缓解的治疗方法。
