Singh R B, Niaz M A, Rastogi S S, Bajaj S, Gaoli Z, Shoumin Z
Center of Nutrition and Heart Research Laboratory, Medical Hospital and Research Center, Moradabad, India.
J Am Coll Nutr. 1998 Dec;17(6):564-70. doi: 10.1080/07315724.1998.10718804.
To determine the association between current zinc intake and prevalence of coronary artery disease (CAD) and diabetes as well as factors associated with insulin resistance.
DESIGN, SUBJECTS AND METHODS: In this cross sectional survey, 3575 subjects, aged 25 to 64 years, including 1769 rural (894 men. 875 women) and 1806 urban (904 men, 902 women) subjects were studied. The survey methods included questionnaires for 7-day food intake record, physical examination, and electrocardiography using World Health Organization criteria.
The prevalence of CAD, diabetes and glucose intolerance was significantly higher among subjects consuming lower intakes of dietary zinc. There was a higher prevalence of hypertension, hypertriglyceridemia and low high-density lipoprotein cholesterol levels which showed significant upward trend with lower zinc intakes. Serum lipoprotein (a) and 2-hour plasma insulin levels also were associated with low zinc intake. Multivariate logistic regression analysis after adjustment for age showed that zinc intake and CAD were inversely associated. Serum zinc (odds ratio:men 0.77, women 0.57), serum triglycerides (men 0.86, women 0.81), blood pressure (0.83 men, women 0.76), diabetes mellitus (men 0.90, women 0.85), central obesity (men 0.88, women 0.87), glucose intolerance (men 0.66, women 0.57) and low high-density lipoprotein cholesterol (men 0.72, women 0.70) were significant risk factors for CAD (explained by tertiles of zinc status) in urban subjects. These associations were not observed in rural subjects.
Lower consumption of dietary zinc and low serum zinc levels were associated with an increased prevalence of CAD and diabetes and several of their associated risk factors including hypertension, hypertriglyceridemia and other factors suggestive of mild insulin resistance in urban subjects.
确定当前锌摄入量与冠状动脉疾病（CAD）和糖尿病患病率以及与胰岛素抵抗相关因素之间的关联。
设计、研究对象与方法：在这项横断面调查中，对3575名年龄在25至64岁之间的对象进行了研究，其中包括1769名农村对象（894名男性，875名女性）和1806名城市对象（904名男性，902名女性）。调查方法包括7天食物摄入量记录问卷、体格检查以及采用世界卫生组织标准进行的心电图检查。
膳食锌摄入量较低的对象中，CAD、糖尿病和葡萄糖耐量异常的患病率显著更高。高血压、高甘油三酯血症和低高密度脂蛋白胆固醇水平的患病率更高，且随着锌摄入量降低呈显著上升趋势。血清脂蛋白（a）和2小时血浆胰岛素水平也与低锌摄入量相关。调整年龄后的多因素逻辑回归分析显示，锌摄入量与CAD呈负相关。血清锌（比值比：男性0.77，女性0.57）、血清甘油三酯（男性0.86，女性0.81）、血压（男性0.83，女性0.76）、糖尿病（男性0.90，女性0.85）、中心性肥胖（男性0.88，女性0.87）、葡萄糖耐量异常（男性0.66，女性0.57）和低高密度脂蛋白胆固醇（男性0.72，女性0.70）是城市对象CAD的显著危险因素（按锌状态三分位数解释）。在农村对象中未观察到这些关联。
膳食锌摄入量较低和血清锌水平较低与城市对象中CAD和糖尿病患病率增加以及包括高血压、高甘油三酯血症和其他提示轻度胰岛素抵抗的因素在内的几种相关危险因素有关。
