Müller R A, Rothermel R D, Behen M E, Muzik O, Mangner T J, Chugani H T
Department of Pediatrics, Wayne State University Medical School, Detroit, MI, USA.
J Child Neurol. 1998 Nov;13(11):550-6. doi: 10.1177/088307389801301105.
Functional neuroimaging data regarding the development of motor organization in normal children and adolescents are virtually unavailable because of ethical concerns. As an alternative approach, we studied child and adult lesion patients, focusing on movement of the hand ipsilateral to the lesion and on brain activations in the contralesional hemisphere. [15O]-water positron emission tomography was performed during rest and sequential finger-thumb tapping in 10 children (aged 6 to 14 years) and 15 adults (aged 18 to 74 years) with unilateral lesion. We expected more distinct activation/deactivation patterns during movement in adults than in children. While there were no group differences in activation of primary and secondary motor cortices, deactivations in nonmotor cortex were significantly more pronounced in adults than in children. This indirectly supports our hypothesis of developmental focalization of cerebral motor control. Activations in the cerebellum and vermis were significantly stronger in the adults than in the children, possibly reflecting normal developmental patterns.
由于伦理方面的考虑，几乎没有关于正常儿童和青少年运动组织发育的功能性神经影像学数据。作为一种替代方法，我们研究了儿童和成人脑损伤患者，重点关注损伤同侧手的运动以及对侧半球的脑激活情况。对10名（6至14岁）儿童和15名（18至74岁）成人单侧脑损伤患者在静息状态和连续进行拇指对指轻敲时进行了[15O] - 水正电子发射断层扫描。我们预期成人在运动过程中的激活/去激活模式比儿童更明显。虽然初级和次级运动皮层的激活在两组之间没有差异，但非运动皮层的去激活在成人中比在儿童中明显更显著。这间接支持了我们关于大脑运动控制发育集中化的假设。成人小脑和蚓部的激活明显强于儿童，这可能反映了正常的发育模式。
