Reitz M, Müller K
Medizinische Einrichtungen der Heinrich-Heine-Universität, Zentrum für Kinderheilkunde, Düsseldorf, Germany.
Neurosci Lett. 1998 Nov 6;256(2):69-72. doi: 10.1016/s0304-3940(98)00748-4.
In this study we analysed how far physiological associated movements in normal children (which may be present up to the age of 10 years) share the same physiological mechanism with clinically apparent mirror movements. Transcranial magnetic stimulation (TMS) and kinematic movement analysis were applied in a 4-year-old child with congenital mirror movements (CMM). The results were compared with a normative data base of clinically normal children. In the child with CMM focal TMS of one motor cortex induced bilaterally symmetrical responses in distal and proximal upper extremities muscles with identical ipsi- and contralateral latencies. Also kinematic analysis showed a precise symmetrical onset of intended and unintended contralateral movements, whereas normal children with associated movements showed a variable movement onset delay between extremities. The data suggest a different physiological mechanism underlying these two varieties of elementary associated motor activity in childhood.
在本研究中，我们分析了正常儿童（可能在10岁之前出现）与生理相关的运动在多大程度上与临床上明显的镜像运动具有相同的生理机制。对一名患有先天性镜像运动（CMM）的4岁儿童进行了经颅磁刺激（TMS）和运动学运动分析。将结果与临床正常儿童的标准数据库进行比较。在患有CMM的儿童中，对一侧运动皮层进行局灶性TMS会在远端和近端上肢肌肉中诱发双侧对称反应，同侧和对侧潜伏期相同。运动学分析还显示，预期和非预期的对侧运动精确对称地开始，而有相关运动的正常儿童在四肢之间表现出可变的运动开始延迟。数据表明，童年时期这两种基本相关运动活动的生理机制不同。
