Thach B T, Taeusch H W
J Appl Physiol. 1976 Oct;41(4):502-7. doi: 10.1152/jappl.1976.41.4.502.
To investigate the reflex mechanisms of sighs (spontaneous large breaths) (VT greater than 2 X control VT) in infants, recordings of respiratory flow and tidal volume (VT) were made during sleep. The frequency of sighs was greater at 1 than at 5 days of age, while respiratory frequency and control VT did not change. Most sighs (93%) had a biphasic pattern of inspiratory flow characterized by an inspiratory duration nearly twice that of control breaths, with an abrupt change in flow rate halfway through inspiration. Interruption of ventilation (3-7 s of airway occlusion) appeared to generate a stimulus for biphasic sighs, since sighs occurred during the first breath after termination of airway occlusion more frequently after long than after brief occlusions. However, a biphasic inspiratory pattern in airway pressure was rarely observed while the airways were occluded, regardless of occlusion duration. This suggests that increase in lung volume during the initial part of the biphasic inspiration following occlusion is a stimulus for the second part. Thus the underlying reflex mechanism of sighs in human infants appears to be the same as occurs in the so-called Head's paradoxical response to lung inflation.
为研究婴儿叹息（自发的深呼吸，潮气量大于对照潮气量的2倍）的反射机制，在睡眠期间记录呼吸流量和潮气量（VT）。叹息频率在1日龄时高于5日龄，而呼吸频率和对照潮气量未发生变化。大多数叹息（93%）具有双相吸气流量模式，其吸气持续时间几乎是对照呼吸的两倍，在吸气中途流速突然改变。通气中断（气道阻塞3 - 7秒）似乎会产生双相叹息的刺激，因为在气道阻塞终止后的第一次呼吸时，长时间阻塞后比短时间阻塞后更频繁地出现叹息。然而，无论阻塞持续时间如何，在气道阻塞时很少观察到气道压力的双相吸气模式。这表明阻塞后双相吸气初始阶段肺容积的增加是第二阶段的刺激因素。因此，人类婴儿叹息的潜在反射机制似乎与所谓的海德对肺膨胀的反常反应相同。
