Sabbe L J, Van De Merwe D, Schouls L, Bergmans A, Vaneechoutte M, Vandamme P
Regional Lab for Public Health "Zeeland," 4460 AA Goes, The Netherlands.
J Clin Microbiol. 1999 Jan;37(1):8-13. doi: 10.1128/JCM.37.1.8-13.1999.
Over a 7-year period, we isolated 294 Actinomyces-like organisms (ALOs) which were not clearly identifiable. Using well-defined probes coding for sequences specific for recently described Actinomyces species (A. turicensis, A. radingae, and A. europaeus), we were able to identify 128 strains. The majority belonged to the A. turicensis species. A. radingae was found only in patients with skin-related pathologies. A. europaeus was also detected in patients with urinary tract infections. The main sources of A. turicensis were genital infections, followed by skin-related and urinary tract infections. Additional clinical pictures were appendicitis, cholecystitis, ear, nose, and throat infections, and bacteremia. In a small number of patients these ALOs were found as the only pathogen. Strains of the three species were tested by two widely used biochemical identification methods. A. turicensis was easily identifiable by both these methods. We conclude that these ALOs are not infrequent pathogens and are found in a wide range of human infections. At least A. turicensis is easily identifiable by clinical diagnostic laboratories.
在7年的时间里，我们分离出了294株难以明确鉴定的类放线菌（ALOs）。使用针对最近描述的放线菌物种（土生放线菌、拉氏放线菌和欧洲放线菌）的特定序列编码的明确探针，我们能够鉴定出128株菌株。大多数属于土生放线菌物种。拉氏放线菌仅在患有皮肤相关疾病的患者中发现。欧洲放线菌也在尿路感染患者中检测到。土生放线菌的主要来源是生殖器感染，其次是皮肤相关感染和尿路感染。其他临床症状包括阑尾炎、胆囊炎、耳鼻喉感染和菌血症。在少数患者中，这些ALOs被发现是唯一的病原体。这三个物种的菌株通过两种广泛使用的生化鉴定方法进行了测试。这两种方法都很容易鉴定出土生放线菌。我们得出结论，这些ALOs是常见的病原体，存在于广泛的人类感染中。至少土生放线菌很容易被临床诊断实验室鉴定出来。
