台湾地区高水平耐青霉素、耐广谱头孢菌素及耐红霉素肺炎链球菌克隆株的传播情况
Dissemination of high-level penicillin-, extended-spectrum cephalosporin-, and erythromycin-resistant Streptococcus pneumoniae clones in Taiwan.
作者信息
Hsueh P R, Teng L J, Lee L N, Yang P C, Ho S W, Luh K T
机构信息
Departments of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
出版信息
J Clin Microbiol. 1999 Jan;37(1):221-4. doi: 10.1128/JCM.37.1.221-224.1999.
Abstract
Sixty-seven clinical isolates of Streptococcus pneumoniae (40 of serotype 23F, 19 of serotype 19F, and 8 of serotype 6B) with decreased susceptibilities to penicillin and erythromycin were characterized by antimicrobial susceptibility patterns; DNA restriction endonuclease cleavage profiles of the penicillin-binding protein genes pbp1a, pbp2b, and pbp2x; random amplified polymorphic DNA (RAPD) patterns generated by arbitrarily primed PCR; and chromosomal macrorestriction profiles based on pulsed-field gel electrophoresis. A total of 22 clones (identical or closely related pulsotypes and identical RAPD patterns) were identified; 14 clones of 23F, 6 of 19F, and 2 of 6B. Three 23F clones (26 isolates) and one 19F clone (9 isolates) expressed high-level resistance to penicillin, cefotaxime, and erythromycin (MICs >/= 256 microg/ml). These data strongly suggest that multiple high-level penicillin-, extended-spectrum cephalosporin-, and macrolide-resistant clones of S. pneumoniae have been disseminated in Taiwan.
摘要
对67株对青霉素和红霉素敏感性降低的肺炎链球菌临床分离株（40株23F血清型、19株19F血清型和8株6B血清型）进行了抗菌药敏模式、青霉素结合蛋白基因pbp1a、pbp2b和pbp2x的DNA限制性内切酶切割图谱、任意引物PCR产生的随机扩增多态性DNA（RAPD）图谱以及基于脉冲场凝胶电泳的染色体宏观限制性图谱分析。共鉴定出22个克隆（相同或密切相关的脉冲型和相同的RAPD图谱）；23F血清型14个克隆、19F血清型6个克隆和6B血清型2个克隆。三个23F克隆（26株分离株）和一个19F克隆（9株分离株）对青霉素、头孢噻肟和红霉素表现出高水平耐药（最低抑菌浓度≥256μg/ml）。这些数据有力地表明，多重高水平耐青霉素、耐广谱头孢菌素和耐大环内酯的肺炎链球菌克隆已在台湾传播。
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