Enomoto H, Watanabe H, Nishikura K, Umezawa H, Asakura H
First Department of Pathology, Niigata University School of Medicine, Japan.
Eur J Gastroenterol Hepatol. 1998 Jun;10(6):473-8. doi: 10.1097/00042737-199806000-00007.
The aim of this study was to elucidate the prevalence of Helicobacter pylori and its distribution in order to clarify the frequency of H. pylori infection and the most appropriate site of endoscopic biopsy for studies of H. pylori infection associated with different gastric diseases.
Swiss role mucosal strips from 275 resected stomachs, which included the greater curvature, anterior wall and lesser curvature of the antrum, incisura and corpus, were stained with haematoxylin-eosin and H. pylori antibody.
The prevalence of H. pylori infection was 97% in duodenal ulcers, 98% in gastric ulcers, 98% in intestinal-type carcinomas and 99% in diffuse-type carcinomas. H. pylori was present at a rate of 100% in any site in cases of duodenal ulcer, but was diffusely distributed in the antrum and patchily distributed in the corpus. The detection rate of H. pylori was 50-100% in gastric ulcers, 30-100% in intestinal-type adenocarcinomas and 63-100% in diffuse-type adenocarcinomas depending on the site of the stomach examined.
The prevalence of H. pylori infection was very high in peptic ulcers of the duodenum and stomach and gastric carcinomas of Japanese patients. Biopsy specimens for evaluation of H. pylori infection should be taken routinely from both the greater curvature of the antrum and corpus. Immunohistochemical staining should be used to assay for H. pylori when few organisms are present or eradication therapy has been used.
本研究旨在阐明幽门螺杆菌的患病率及其分布情况，以明确幽门螺杆菌感染的频率，以及针对与不同胃部疾病相关的幽门螺杆菌感染研究，确定最合适的内镜活检部位。
对275例切除胃的瑞士卷状黏膜条进行苏木精-伊红染色和幽门螺杆菌抗体染色，这些黏膜条包括胃窦大弯、前壁、小弯、切迹和胃体。
十二指肠溃疡患者中幽门螺杆菌感染率为97%，胃溃疡患者中为98%，肠型癌患者中为98%，弥漫型癌患者中为99%。十二指肠溃疡患者的任何部位幽门螺杆菌检出率均为100%，但在胃窦呈弥漫分布，在胃体呈散在分布。根据所检查胃的部位不同，胃溃疡患者中幽门螺杆菌的检出率为50%-100%，肠型腺癌患者中为30%-100%，弥漫型腺癌患者中为63%-100%。
日本患者十二指肠和胃部消化性溃疡以及胃癌中幽门螺杆菌感染率非常高。评估幽门螺杆菌感染的活检标本应常规取自胃窦大弯和胃体。当细菌数量较少或已进行根除治疗时，应采用免疫组织化学染色检测幽门螺杆菌。
