阿尔茨海默病与衰老中的核糖体RNA

Ribosomal RNA in Alzheimer's disease and aging.

作者信息

Payão S L, Smith M A, Winter L M, Bertolucci P H

机构信息

Departamento de Morfologia, Disciplina de Genética, UNIFESP Escola Paulista de Medicina, São Paulo, Brazil.

出版信息

Mech Ageing Dev. 1998 Nov 16;105(3):265-72. doi: 10.1016/s0047-6374(98)00095-5.

DOI:10.1016/s0047-6374(98)00095-5

PMID:9862234

Abstract

Ribosomal RNA genes are involved in cell transcription and translation processes and can modulate gene expression. In an earlier cytogenetic study, (Payão, S.L.M., Smith, M.de A.C., Kormann-Bortolotto, M.H., Toniolo, J., 1994 (Investigation of the nucleolar organizer regions in Alzheimer's disease. Gerontology 40, 13-17), reported a decreased activity of ribosomal genes in Alzheimer's disease (AD). We studied the ratio of mature rRNA 28S and 18S in peripheral blood samples derived from eight patients with AD, eight healthy elderly sisters of these patients (SA), eight healthy elderly (EC) and eight healthy young (YC) controls, all female. Our results showed a statistically significant decrease of mature rRNA 28S and 18S ratio in the elderly groups (AD, SA, EC) in relation to the young one, probably by fragmentation of 28S rRNA. The Alzheimer's patient group had the lowest 28S/18S ratio. Thus, we can suggest that there is a possible change in the transcriptional or maturation process, or a preferential degradation of the 28S subunit with ageing.

摘要

核糖体RNA基因参与细胞转录和翻译过程，并可调节基因表达。在一项早期的细胞遗传学研究中，（Payão, S.L.M., Smith, M.de A.C., Kormann-Bortolotto, M.H., Toniolo, J., 1994年（阿尔茨海默病中核仁组织区的研究。老年医学40, 13 - 17））报道了阿尔茨海默病（AD）中核糖体基因活性降低。我们研究了来自8名AD患者、8名这些患者的健康老年姐妹（SA）、8名健康老年人（EC）和8名健康年轻人（YC）对照（均为女性）的外周血样本中成熟rRNA 28S和18S的比例。我们的结果显示，老年组（AD、SA、EC）中成熟rRNA 28S和18S的比例相对于年轻组在统计学上有显著下降，可能是由于28S rRNA的片段化。阿尔茨海默病患者组的28S/18S比例最低。因此，我们可以推测，随着年龄增长，转录或成熟过程可能发生变化，或者28S亚基存在优先降解。