牙周炎患者血清中可溶性CD14水平升高。
Increased levels of soluble CD14 in sera of periodontitis patients.
作者信息
Hayashi J, Masaka T, Ishikawa I
机构信息
Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.
出版信息
Infect Immun. 1999 Jan;67(1):417-20. doi: 10.1128/IAI.67.1.417-420.1999.
Abstract
Soluble CD14 (sCD14) mediates the response to lipopolysaccharide (LPS) in cells lacking membrane-bound CD14. We determined sCD14 concentrations in the sera of 38 periodontitis patients and 25 healthy controls by enzyme-linked immunosorbent assay. The sCD14 levels in the sera of patients with periodontitis were significantly higher than those of healthy subjects and decreased after treatment. Enhanced levels of sCD14 in serum may contribute to the host response to LPS in periodontitis. Furthermore, we showed in vitro that addition of LPS enhanced the release of sCD14 by monoblastic U937 cells treated with 1alpha,25-dihydroxyvitamin D3. Thus, increased sCD14 levels in periodontitis patients may be due to chronic exposure to LPS.
摘要
可溶性CD14（sCD14）介导缺乏膜结合型CD14的细胞对脂多糖（LPS）的反应。我们通过酶联免疫吸附测定法测定了38例牙周炎患者和25名健康对照者血清中的sCD14浓度。牙周炎患者血清中的sCD14水平显著高于健康受试者，且治疗后降低。血清中sCD14水平的升高可能有助于宿主对牙周炎中LPS的反应。此外，我们在体外表明，添加LPS可增强经1α,25-二羟基维生素D3处理的单核细胞U937细胞释放sCD14。因此，牙周炎患者sCD14水平升高可能是由于长期接触LPS所致。
相似文献
1
Increased levels of soluble CD14 in sera of periodontitis patients.牙周炎患者血清中可溶性CD14水平升高。
Infect Immun. 1999 Jan;67(1):417-20. doi: 10.1128/IAI.67.1.417-420.1999.
2
Soluble CD14 Enhances the Response of Periodontal Ligament Stem Cells to Toll-Like Receptor 2 Agonists.可溶性 CD14 增强牙周膜干细胞对 Toll 样受体 2 激动剂的反应。
Mediators Inflamm. 2019 Apr 23;2019:8127301. doi: 10.1155/2019/8127301. eCollection 2019.
3
Function of soluble CD14 in serum from patients with septic shock.脓毒性休克患者血清中可溶性CD14的功能
J Infect Dis. 1996 Mar;173(3):661-8. doi: 10.1093/infdis/173.3.661.
4
Is the activity of soluble CD14 enhanced following major trauma?
Arch Surg. 1997 Oct;132(10):1116-20. doi: 10.1001/archsurg.1997.01430340070011.
5
Monocyte cell-surface CD14 expression and soluble CD14 antigen in hemodialysis: evidence for chronic exposure to LPS.血液透析中单核细胞表面CD14表达及可溶性CD14抗原：长期暴露于脂多糖的证据
Kidney Int. 1995 Nov;48(5):1469-76. doi: 10.1038/ki.1995.436.
6
A novel flow cytometric assay to quantify soluble CD14 concentration in human serum.一种用于定量人血清中可溶性CD14浓度的新型流式细胞术检测方法。
Cytometry. 2001 Oct 1;45(2):115-23. doi: 10.1002/1097-0320(20011001)45:2<115::aid-cyto1153>3.0.co;2-m.
7
CD14 is an acute-phase protein.CD14是一种急性期蛋白。
J Immunol. 2004 Apr 1;172(7):4470-9. doi: 10.4049/jimmunol.172.7.4470.
8
Soluble CD14 and lipopolysaccharide-binding protein from bovine serum enable bacterial lipopolysaccharide-mediated cytotoxicity and activation of bovine vascular endothelial cells in vitro.来自牛血清的可溶性CD14和脂多糖结合蛋白可在体外使细菌脂多糖介导牛血管内皮细胞的细胞毒性和激活。
J Leukoc Biol. 1996 Feb;59(2):241-7. doi: 10.1002/jlb.59.2.241.
9
Characteristics of CD14 shedding from human monocytes. Evidence for the competition of soluble CD14 (sCD14) with CD14 receptors for lipopolysaccharide (LPS) binding.
APMIS. 1997 Jul;105(7):510-8. doi: 10.1111/j.1699-0463.1997.tb05048.x.
10
Soluble CD14 levels reflect liver inflammation in patients with nonalcoholic steatohepatitis.可溶性 CD14 水平反映非酒精性脂肪性肝炎患者的肝脏炎症。
PLoS One. 2013 Jun 7;8(6):e65211. doi: 10.1371/journal.pone.0065211. Print 2013.
引用本文的文献
1
Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia.牙周炎与心脏代谢紊乱：脂多糖和内毒素血症的作用。
Periodontol 2000. 2022 Jun;89(1):19-40. doi: 10.1111/prd.12433. Epub 2022 Mar 4.
2
Connection between Periodontitis-Induced Low-Grade Endotoxemia and Systemic Diseases: Neutrophils as Protagonists and Targets.牙周炎诱导的低度内毒素血症与全身性疾病之间的联系：中性粒细胞作为主角和靶点
Int J Mol Sci. 2021 Apr 28;22(9):4647. doi: 10.3390/ijms22094647.
3
Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis.类风湿关节炎患者的抗菌反应因子水平升高。
Front Immunol. 2020 Mar 20;11:427. doi: 10.3389/fimmu.2020.00427. eCollection 2020.
4
Epigenetic findings in periodontitis in UK twins: a cross-sectional study.牙周炎中表观遗传学发现：英国双胞胎的横断面研究。
Clin Epigenetics. 2019 Feb 13;11(1):27. doi: 10.1186/s13148-019-0614-4.
5
Presepsin (scd14) as a marker of serious bacterial infections in chemotherapy induced severe neutropenia.可溶性髓系细胞触发受体-1（Presepsin，scd14）作为化疗诱导的严重中性粒细胞减少症中严重细菌感染的标志物。
Iran J Pediatr. 2014 Dec;24(6):715-22. Epub 2014 Nov 28.
6
Porphyromonas gingivalis lipopolysaccharide upregulates insulin secretion from pancreatic β cell line MIN6.牙龈卟啉单胞菌脂多糖上调胰腺β细胞系MIN6的胰岛素分泌。
J Periodontol. 2014 Nov;85(11):1629-36. doi: 10.1902/jop.2014.140070. Epub 2014 Jun 12.
7
Clinical application of human β-defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation.人β防御素和 CD14 基因多态性在评估慢性炎症状态中的临床应用。
J Transl Med. 2012 Sep 19;10 Suppl 1(Suppl 1):S9. doi: 10.1186/1479-5876-10-S1-S9.
8
Cardiovascular disease and the role of oral bacteria.心血管疾病与口腔细菌的作用。
J Oral Microbiol. 2010 Dec 21;2. doi: 10.3402/jom.v2i0.5781.
9
Regulation of endotoxin-induced proinflammatory activation in human coronary artery cells: expression of functional membrane-bound CD14 by human coronary artery smooth muscle cells.内毒素诱导人冠状动脉细胞促炎激活的调节：人冠状动脉平滑肌细胞功能性膜结合CD14的表达
J Immunol. 2004 Jul 15;173(2):1336-43. doi: 10.4049/jimmunol.173.2.1336.
10
Effect of CD14 promoter polymorphism and H. pylori infection and its clinical outcomes on circulating CD14.CD14启动子多态性、幽门螺杆菌感染及其临床结局对循环CD14的影响。
Clin Exp Immunol. 2002 May;128(2):326-32. doi: 10.1046/j.1365-2249.2002.01837.x.
本文引用的文献
1
Interactions between periodontal disease, medical diseases and immunity in the older individual.
Periodontol 2000. 1998 Feb;16:80-105. doi: 10.1111/j.1600-0757.1998.tb00117.x.
2
Soluble CD14 mediates lipopolysaccharide-induced intercellular adhesion molecule 1 expression in cultured human gingival fibroblasts.可溶性CD14介导脂多糖诱导培养的人牙龈成纤维细胞中细胞间黏附分子1的表达。
Infect Immun. 1996 Dec;64(12):4946-51. doi: 10.1128/iai.64.12.4946-4951.1996.
3
Periodontal disease and cardiovascular disease.牙周病与心血管疾病。
J Periodontol. 1996 Oct;67(10 Suppl):1123-37. doi: 10.1902/jop.1996.67.10s.1123.
4
Periodontal infection as a possible risk factor for preterm low birth weight.牙周感染作为早产低出生体重的一个可能风险因素。
J Periodontol. 1996 Oct;67(10 Suppl):1103-13. doi: 10.1902/jop.1996.67.10s.1103.
5
Increased serum concentration of soluble CD14 is a prognostic marker in gram-positive sepsis.可溶性CD14血清浓度升高是革兰氏阳性菌败血症的一个预后标志物。
Clin Immunol Immunopathol. 1996 Sep;80(3 Pt 1):307-10. doi: 10.1006/clin.1996.0128.
6
Elevated levels of soluble CD14 in serum of patients with acute Plasmodium falciparum malaria.急性恶性疟原虫疟疾患者血清中可溶性CD14水平升高。
Clin Exp Immunol. 1996 Jul;105(1):74-8. doi: 10.1046/j.1365-2249.1996.d01-723.x.
7
Human monocyte CD14 is upregulated by lipopolysaccharide.人单核细胞CD14被脂多糖上调。
Infect Immun. 1996 May;64(5):1762-9. doi: 10.1128/iai.64.5.1762-1769.1996.
8
Monocyte cell-surface CD14 expression and soluble CD14 antigen in hemodialysis: evidence for chronic exposure to LPS.血液透析中单核细胞表面CD14表达及可溶性CD14抗原：长期暴露于脂多糖的证据
Kidney Int. 1995 Nov;48(5):1469-76. doi: 10.1038/ki.1995.436.
9
Cell-free pool of CD14 mediates activation of transcription factor NF-kappa B by lipopolysaccharide in human endothelial cells.人内皮细胞中无细胞状态的CD14池介导脂多糖对转录因子NF-κB的激活。
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):9887-91. doi: 10.1073/pnas.90.21.9887.
10
Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide.重组可溶性CD14介导脂多糖对内皮细胞的激活作用。
J Immunol. 1993 Aug 1;151(3):1500-7.
Zotero 插件