氯喹抑制HIV-1在人外周血淋巴细胞中的复制。
Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes.
作者信息
Pardridge W M, Yang J, Diagne A
机构信息
Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1682, USA.
出版信息
Immunol Lett. 1998 Nov;64(1):45-7. doi: 10.1016/s0165-2478(98)00096-0.
Chloroquine has inhibitory effects on human immunodeficiency deficiency virus (HIV)-1 replication in human lymphocytes with an ED50 of 15 microM, which approximates the chloroquine plasma concentration generated in the acute treatment of malaria. Chloroquine has a parallel inhibitory effect on DNA replication in human lymphocytes, although the inhibitory effect on DNA replication is not as pronounced as is the drug inhibition of HIV-1 replication in the cells.
氯喹对人类淋巴细胞中的人类免疫缺陷病毒（HIV）-1复制具有抑制作用，其半数有效剂量（ED50）为15微摩尔，这一数值接近疟疾急性治疗时所产生的氯喹血浆浓度。氯喹对人类淋巴细胞中的DNA复制具有类似的抑制作用，尽管其对DNA复制的抑制作用不如对细胞中HIV-1复制的药物抑制作用那么明显。
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