Iwanami A, Kuroki N, Iritani S, Isono H, Okajima Y, Kamijima K
Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan.
J Nerv Ment Dis. 1998 Dec;186(12):746-51. doi: 10.1097/00005053-199812000-00002.
To investigate the psychophysiological features of methamphetamine (MAP) dependence, we recorded auditory event-related potentials (ERPs) in 15 patients with MAP dependence and in 15 age-matched normal controls. ERPs were recorded during a standard oddball task and a read task similar to those employed by Squires et al. (Squires NK, Squires KC, Hillyard SA [1975] Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. Electroenceph Clin Neurophysiol 38:387-401). The patients with MAP dependence showed reduced P3a amplitude and area in the read task and delayed P3b latency with normal P3b amplitude and area in the oddball task. These results suggest that central noradrenergic dysregulation may persist after the remission of acute psychotic symptoms in MAP psychosis and that chronic MAP dependence would produce impairment of the frontal cortex.
为研究甲基苯丙胺（MAP）依赖的心理生理特征，我们记录了15例MAP依赖患者及15名年龄匹配的正常对照者的听觉事件相关电位（ERP）。ERP记录于标准的oddball任务及一项与Squires等人所采用任务类似的阅读任务期间（Squires NK, Squires KC, Hillyard SA [1975] 人类不可预测听觉刺激诱发的两种长潜伏期正波。《脑电图与临床神经生理学》38:387 - 401）。MAP依赖患者在阅读任务中P3a波幅和面积降低，在oddball任务中P3b潜伏期延迟，而P3b波幅和面积正常。这些结果表明，在MAP精神病急性精神病性症状缓解后，中枢去甲肾上腺素能调节异常可能持续存在，且慢性MAP依赖会导致额叶皮质受损。
