Jones B E, Prada J A, Martin W R
Psychopharmacology (Berl). 1976 May 5;47(1):7-15. doi: 10.1007/BF00428694.
A method for an economical bioassay of physical dependence on sedatives is presented. Dogs maintained on sodium pentobarbital (200 mg/kg/24 h i.v.) were given periodic graded reductions in maintenance dose, and subscales for measuring signs of abstinence were developed. Using these subscales the relative potencies compared with sodium pentobarbital were determined for sodium secobarbital (RP = 0.85) and methaqualone (RP = 0.14). Sodium thiopental and methaqualone were assayed and found to be equipotent (RP = 0.96) in reducing the signs of abstinence from sodium pentobarbital. The occurrence of convulsions, during periods of complete reduction of the maintenance drug, became less frequent the longer the dogs had been maintained on a constant dose of sodium pentobarbital.
本文介绍了一种对镇静剂身体依赖性进行经济生物测定的方法。给维持戊巴比妥钠（静脉注射，200毫克/千克/24小时）的犬只定期逐步减少维持剂量，并制定了用于测量戒断症状的分量表。使用这些分量表，确定了司可巴比妥钠（相对效价=0.85）和甲喹酮（相对效价=0.14）相对于戊巴比妥钠的相对效价。对硫喷妥钠和甲喹酮进行了测定，发现它们在减轻戊巴比妥钠戒断症状方面具有同等效力（相对效价=0.96）。在完全停用维持药物期间，惊厥的发生频率随着犬只维持恒定剂量戊巴比妥钠的时间延长而降低。
