Campbell L A, Kuo C C, Grayston J T
Department of Pathobiology, University of Washington, Seattle 98195, USA.
Emerg Infect Dis. 1998 Oct-Dec;4(4):571-9. doi: 10.3201/eid0404.980407.
Chlamydia pneumoniae is a ubiquitous pathogen that causes acute respiratory disease. The spectrum of C. pneumoniae infection has been extended to atherosclerosis and its clinical manifestations. Seroepidemiologic studies have associated C. pneumoniae antibody with coronary artery disease, myocardial infarction, carotid artery disease, and cerebrovascular disease. The association of C. pneumoniae with atherosclerosis is corroborated by the presence of the organism in atherosclerotic lesions throughout the arterial tree and the near absence of the organism in healthy arterial tissue. C. pneumoniae has also been isolated from coronary and carotid atheromatous plaques. To determine whether chronic infection plays a role in initiation or progression of disease, intervention studies in humans have been initiated, and animal models of C. pneumoniae infection have been developed. This review summarizes the evidence for the association and potential role of C. pneumoniae in cardiovascular disease.
肺炎衣原体是一种引起急性呼吸道疾病的普遍存在的病原体。肺炎衣原体感染的范围已扩展至动脉粥样硬化及其临床表现。血清流行病学研究已将肺炎衣原体抗体与冠状动脉疾病、心肌梗死、颈动脉疾病和脑血管疾病联系起来。在整个动脉树的动脉粥样硬化病变中存在该病原体，而在健康动脉组织中几乎不存在，这证实了肺炎衣原体与动脉粥样硬化之间的关联。肺炎衣原体也已从冠状动脉和颈动脉粥样斑块中分离出来。为了确定慢性感染是否在疾病的发生或发展中起作用，已启动了人类干预研究，并建立了肺炎衣原体感染的动物模型。本综述总结了肺炎衣原体与心血管疾病之间关联及潜在作用的证据。
