Bowers W S, Ohta T, Cleere J S, Marsella P A
Science. 1976 Aug 13;193(4253):542-7. doi: 10.1126/science.986685.
Two simple chromenes with anti-JH activity have been isolated and identified from the bedding plant Ageratum houstoianum. By contact and fumigation these compounds induce precocious metamorphosis and sterilization in several hemipteran species of insects. Certain holometabolous species are sterilized, forced into diapause, or both. Each of these biological actions is equivalent to removal of the corpora allata, which produce the JH's, and is reversible by treatment with exogenous JH. Thus, the action of these compounds is to stop the production or depress the titer of the JH's. To our knowledge, this is the first discovery of anti-JH, and we hope it will guide the way to the emergence of a fourth generation of safe and insect-specific pesticides.
从花坛植物藿香蓟中分离并鉴定出了两种具有抗保幼激素活性的简单色烯。通过接触和熏蒸，这些化合物能在几种半翅目昆虫中诱导早熟变态和绝育。某些全变态昆虫种类会被绝育、被迫进入滞育状态，或两者皆有。这些生物学作用中的每一种都等同于切除产生保幼激素的咽侧体，并且通过用外源性保幼激素处理可以逆转。因此，这些化合物的作用是阻止保幼激素的产生或降低其滴度。据我们所知，这是抗保幼激素的首次发现，我们希望它将为第四代安全且针对昆虫的杀虫剂的出现指明方向。
