鉴定与肺炎链球菌氟喹诺酮耐药性相关的外排泵基因pmrA。
Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae.
作者信息
Gill M J, Brenwald N P, Wise R
机构信息
Division of Immunity and Infection, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1999 Jan;43(1):187-9. doi: 10.1128/AAC.43.1.187.
Abstract
An open reading frame (ORF) homologous to norA was insertionally inactivated with cat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggests that it is a major facilitator system pump of the 12-transmembrane-segment class.
摘要
在一株具有外排表型的耐氟喹诺酮肺炎球菌中，与norA同源的一个开放阅读框（ORF）被cat插入失活；这种失活导致菌株恢复对药物的敏感性。该ORF产物与NorA和Bmr的氨基酸序列一致性均为24%，这表明它是一种12跨膜片段类的主要易化子系统泵。
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