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Prevalence of a putative efflux mechanism among fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae.肺炎链球菌耐氟喹诺酮临床分离株中一种假定外排机制的流行情况。
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SOSUI: classification and secondary structure prediction system for membrane proteins.SOSUI：膜蛋白分类及二级结构预测系统
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Cloning and expression of pneumococcal genes in Streptococcus pneumoniae.肺炎链球菌中肺炎球菌基因的克隆与表达
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The effect of reserpine, an inhibitor of multi-drug efflux pumps, on the in-vitro susceptibilities of fluoroquinolone-resistant strains of Streptococcus pneumoniae to norfloxacin.利血平（一种多药外排泵抑制剂）对耐氟喹诺酮类肺炎链球菌菌株体外对诺氟沙星敏感性的影响。
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Active efflux as a mechanism of resistance to ciprofloxacin in Streptococcus pneumoniae.主动外排作为肺炎链球菌对环丙沙星耐药的一种机制。
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Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.多药转运蛋白明显参与肺炎链球菌对氟喹诺酮类药物的耐药性。
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Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes--an analysis.真核生物和原核生物中涉及抗生素和防腐剂抗性的两类蛋白质的拓扑结构、结构与进化——一项分析
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An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae.一种未修饰的十七肽信息素可诱导肺炎链球菌发生遗传转化的感受态。
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鉴定与肺炎链球菌氟喹诺酮耐药性相关的外排泵基因pmrA。

Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae.

作者信息

Gill M J, Brenwald N P, Wise R

机构信息

Division of Immunity and Infection, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom.

出版信息

Antimicrob Agents Chemother. 1999 Jan;43(1):187-9. doi: 10.1128/AAC.43.1.187.

DOI:10.1128/AAC.43.1.187
PMID:9869592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89047/
Abstract

An open reading frame (ORF) homologous to norA was insertionally inactivated with cat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggests that it is a major facilitator system pump of the 12-transmembrane-segment class.

摘要

在一株具有外排表型的耐氟喹诺酮肺炎球菌中，与norA同源的一个开放阅读框（ORF）被cat插入失活；这种失活导致菌株恢复对药物的敏感性。该ORF产物与NorA和Bmr的氨基酸序列一致性均为24%，这表明它是一种12跨膜片段类的主要易化子系统泵。