Raith K, Althoff E, Banse J, Neidhardt H, Neubert R H
Martin Luther University Halle, Department of Pharmacy, Institute of Pharmaceutics and Biopharmaceutics, Halle (Saale), Germany.
Electrophoresis. 1998 Nov;19(16-17):2907-11. doi: 10.1002/elps.1150191618.
Capillary electrophoresis is a versatile tool in pharmaceutical analysis. In the course of a revision of the "Standardrezepturen", a German formula of standard dispensings for preparation in pharmacies, this technique has been applied to drug analysis in pharmaceutical formulations. The present paper deals with two different examples. First, naphazoline, dexamethasone and the preservative benzalkonium are quantified in nose drops without any sample preparation. Second, the antifungal antibiotic nystatin is quantified using nonaqueous capillary electrophoresis in methanol after sample preparation from an oily suspension.
毛细管电泳是药物分析中一种多功能工具。在修订《标准配方》（德国药房制剂标准配药配方）过程中，该技术已应用于药物制剂的药物分析。本文涉及两个不同的例子。第一，滴鼻剂中的萘甲唑啉、地塞米松和防腐剂苯扎氯铵无需任何样品前处理即可进行定量分析。第二，油性混悬液经样品前处理后，采用非水毛细管电泳法在甲醇中对抗真菌抗生素制霉菌素进行定量分析。
