Sporn M B, Dunlop N M, Newton D L, Henderson W R
Nature. 1976 Sep 9;263(5573):110-3. doi: 10.1038/263110a0.
Structure-function relationships of 19 retinoids were studied in three in vitro systems in defined, serum-free medium. These systems measure effects on differentiation and growth, as well as toxic effects. The ring, side chain, and polar terminal group of natural retinoids all may be modified synthetically to yield highly active compounds. Several retinoid ethers were found to be significantly less toxic than the corresponding carboxylic acids or alcohols.
在限定的无血清培养基中的三种体外系统中研究了19种类视黄醇的结构-功能关系。这些系统可测量对分化、生长以及毒性作用的影响。天然类视黄醇的环、侧链和极性末端基团均可通过合成进行修饰，以产生高活性化合物。发现几种类视黄醇醚的毒性明显低于相应的羧酸或醇。
