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氧中毒会诱导神经元细胞发生凋亡。

Oxygen toxicity induces apoptosis in neuronal cells.

作者信息

Satoh T, Enokido Y, Kubo T, Yamada M, Hatanaka H

机构信息

Division of Protein Biosynthesis, Institute for Protein Research, Osaka University, Japan.

出版信息

Cell Mol Neurobiol. 1998 Dec;18(6):649-66. doi: 10.1023/a:1020633919115.

DOI:10.1023/a:1020633919115
PMID:9876872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11560221/
Abstract
  1. A high oxygen atmosphere induced apoptosis in cultured neuronal cells including PC12 cells and rat embryonic cortical, hippocampal, and basal forebrain neurons associated with DNA fragmentation and nuclear condensation. 2. The sensitivity of CNS neurons to a high-oxygen atmosphere was the following order; cortex > basal forebrain > hippocampus. 3. Cycloheximide and actinomycin-D inhibited the apoptosis, indicating that it depends on new macromolecular synthesis. In contrast, cultured postnatal CNS neurons were resistant to oxidative stress. 4. Neurotrophic factors such as nerve growth factor (NGF), fibroblast growth factor (FGF), and epidermal growth factor (EGF) blocked the apoptosis induced by a high-oxygen atmosphere.
摘要
  1. 高氧环境可诱导培养的神经元细胞（包括PC12细胞以及大鼠胚胎皮质、海马和基底前脑神经元）发生凋亡，这与DNA片段化和核浓缩有关。2. 中枢神经系统神经元对高氧环境的敏感性顺序如下：皮质＞基底前脑＞海马。3. 环己酰亚胺和放线菌素-D可抑制凋亡，表明其依赖于新的大分子合成。相比之下，出生后培养的中枢神经系统神经元对氧化应激具有抗性。4. 神经营养因子，如神经生长因子（NGF）、成纤维细胞生长因子（FGF）和表皮生长因子（EGF）可阻断高氧环境诱导的凋亡。

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本文引用的文献

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Free radical-independent protection by nerve growth factor and Bcl-2 of PC12 cells from hydrogen peroxide-triggered apoptosis.神经生长因子和Bcl-2对PC12细胞的自由基非依赖性保护作用，使其免受过氧化氢引发的细胞凋亡。
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