Saenz de la Calzada C, Ziady G M, Hardarson T, Curiel R, Goodwin J F
Br Heart J. 1976 Aug;38(8):798-803. doi: 10.1136/hrt.38.8.798.
Seventeen patients with hypertropic obstructive cardiomyopathy, were studied using non-invasive techniques before and after the intravenous injection of 5 mg propranolol. The folloeing were analysed: left ventricular ejection time index, derived from the carotid pulse and heart rate; the isovolumic relaxation time, derived from the apex cardiogram and phonocardiogram; the diastolic closure rate of the mirtal valve; and the left ventricular diameters, systolic and diastolic, both measured by echocardiography. Propranolol produced shortening of the isovolumic relaxation time, increase in both the diastolic closure rate of the mitral valve and left ventricular systolic and left ventricular diastolic diameters. These results show that propranolol increases the rate of filling and the volume of the left ventricle, indicating that an improvement in distensibility is produced by beta-adrenergic blockade.
对17例肥厚性梗阻性心肌病患者在静脉注射5毫克普萘洛尔前后采用无创技术进行了研究。分析了以下指标：从颈动脉搏动和心率得出的左心室射血时间指数；从心尖心动图和心音图得出的等容舒张时间；二尖瓣的舒张期关闭速率；以及通过超声心动图测量的左心室收缩期和舒张期直径。普萘洛尔使等容舒张时间缩短，二尖瓣舒张期关闭速率以及左心室收缩期和舒张期直径均增加。这些结果表明，普萘洛尔增加了左心室的充盈速率和容积，提示β-肾上腺素能阻滞剂可改善心室扩张性。
