Morris D M, Hindman J, Marino A A
Department of Surgery, University of New Mexico, ACC 2nd Floor, 2211 Lomas Boulevard NE, 900 Camino de Salud NE, Albuquerque, New Mexico, 87131, USA.
J Surg Res. 1998 Dec;80(2):300-3. doi: 10.1006/jsre.1998.5430.
Hernia repair may involve the use of an implant to augment or replace autologous tissue, but the best material for use in this application has not been established. We developed a dog model to evaluate the mechanical strength of fascial defects repaired using carbon fibers, compared with the strength of similar defects repaired using polypropylene mesh (Marlex). Unrepaired defects were included as an additional control. Bilateral defects (1 cm square) were made in the fascia of the back, and the ultimate mechanical strength and stiffness at the repair sites were measured 3-12 months after operation. Defects repaired with carbon fibers were significantly stronger 12 months after operation compared with defects repaired with polypropylene mesh and compared with unrepaired defects. It is concluded that carbon fibers are biocompatible and significantly increase mechanical strength at the repair site. A randomized clinical trial involving patients undergoing hernia repair seems justified to determine whether carbon fibers are superior to standard therapy.
疝修补术可能涉及使用植入物来增强或替代自体组织，但目前尚未确定用于该应用的最佳材料。我们开发了一种犬模型，以评估使用碳纤维修复的筋膜缺损的机械强度，并与使用聚丙烯网片（Marlex）修复的类似缺损的强度进行比较。未修复的缺损作为额外的对照。在背部筋膜上制造双侧缺损（1平方厘米），并在术后3至12个月测量修复部位的极限机械强度和刚度。与用聚丙烯网片修复的缺损以及未修复的缺损相比，用碳纤维修复的缺损在术后12个月时明显更强。结论是碳纤维具有生物相容性，并且能显著提高修复部位的机械强度。一项涉及接受疝修补术患者的随机临床试验似乎有必要进行，以确定碳纤维是否优于标准治疗。
