Norton S
Brain Res Bull. 1976 Mar-Apr;1(2):193-202. doi: 10.1016/0361-9230(76)90069-1.
Following bilateral lesions of the globus pallidus, rats living in a residential maze were hyperactive during the 12 hr dark cycle but not during the 12 hr light cycle. Lesioned rats were less exploratory during the light cycle than control rats but not during the dark cycle. Exploratory behavior of rats was photographed for 15 min during the light cycle. The duration of 6 behavior acts was significantly shorter than controls (scratching, grooming, sitting, sniffing, standing and rearing). The number of initiations of grooming, scratching, sniffing and smelling decreased while looking and walking increased in frequency. The linkage of behavior acts into sequences was diminished compared with controls. Similar, but not identical, changes were found when the structure of exploratory behavior of naive rats was compared with the exploratory behavior of experienced rats. It is concluded that naive control rats are hyperactive relative to experienced rats in this exploratory situation and that rats with pallidal lesions display changes in their behavior which are characteristic of hyperactive animals even when other tests under similar conditions, such as exploration during the light cycle in a maze, show the pallidal rats as hypoactive relative to control rats.
在双侧苍白球损伤后，生活在居住迷宫中的大鼠在12小时黑暗周期内表现出多动，但在12小时光照周期内则不然。损伤大鼠在光照周期内的探索行为比对照大鼠少，但在黑暗周期内并非如此。在光照周期内对大鼠的探索行为进行了15分钟的拍照。6种行为动作的持续时间明显短于对照组（抓挠、梳理、坐着、嗅闻、站立和竖毛）。梳理、抓挠、嗅闻和闻的起始次数减少，而张望和行走的频率增加。与对照组相比，行为动作序列的关联性减弱。当将未经历过实验的大鼠的探索行为结构与经历过实验的大鼠的探索行为进行比较时，发现了相似但不完全相同的变化。得出的结论是，在这种探索情境中，未经历过实验的对照大鼠相对于经历过实验的大鼠表现出多动，并且苍白球损伤的大鼠表现出行为变化，这些变化是多动动物的特征，即使在类似条件下的其他测试中，例如在迷宫中光照周期内的探索，显示苍白球损伤大鼠相对于对照大鼠表现为活动不足。
