Wang Z Q, Cui J, Wu F, Mao F R, Jin X X
Henan Medical University, Department of Parasitology, Zhengzhou, China.
Acta Trop. 1998 Nov 30;71(3):255-68. doi: 10.1016/s0001-706x(98)00072-2.
The epidemiological, clinical and serological studies on human trichinellosis in Henan Province were carried out from January 1992 to December 1996. The results showed that 467 patients attending our department came from 12 administrative areas and cities of the Province and they acquired the infection mainly by eating undercooked dumplings, tasting the raw pork filling for dumplings, ingesting scalded pork or mutton. There was the high incidence season of trichinellosis during the winter. Most of the patients were workers, officers and merchants aged 20-49 years, and the incidence was higher in males than in females. The main clinical manifestations of trichinellosis were fever, general myalgia, muscle tiredness and eosinophilia. Most of the patients had not any gastrointestinal symptoms and rash. Eyelid edema was only seen in the early courses of the disease. Eosinophil count increased with time, reached to the peak 3 weeks and decreased markedly 6 weeks after the onset of the disease. Eosinophil levels elevated obviously 1 week after therapy, began to drop rapidly 2 weeks after therapy, and decreased to a near normal levels 4 weeks after therapy. Anti-Trichinella antibodies were detected by IFAT using the frozen sections of the purified T. spiralis larvae as antigen. The specific antibodies were observed in only 70.2% of patients one week after onset of disease, and increased to 91, 94.3, and 100%; 2, 3, and 4 weeks, respectively after the onset. The antibody positive rate was evidently increased to 100% 1 week after therapy with abendazole, then decreased to 25% 4 months after therapy.
1992年1月至1996年12月对河南省人体旋毛虫病进行了流行病学、临床及血清学研究。结果显示，我科收治的467例患者来自该省12个行政区和城市，他们主要因食用未煮熟的饺子、品尝生猪肉饺子馅、摄入烫煮的猪肉或羊肉而感染。旋毛虫病有冬季高发季节。多数患者为20 - 49岁的工人、干部和商人，男性发病率高于女性。旋毛虫病的主要临床表现为发热、全身肌痛、肌肉乏力和嗜酸性粒细胞增多。多数患者无任何胃肠道症状和皮疹。眼睑水肿仅在疾病早期出现。嗜酸性粒细胞计数随时间增加，发病后3周达到高峰，6周后明显下降。治疗1周后嗜酸性粒细胞水平明显升高，治疗2周后开始迅速下降，治疗4周后降至接近正常水平。采用纯化旋毛虫幼虫冰冻切片作为抗原，通过间接荧光抗体试验（IFAT）检测抗旋毛虫抗体。发病1周后仅70.2%的患者检测到特异性抗体，发病后2周、3周和4周分别增至91%、94.3%和100%。阿苯达唑治疗1周后抗体阳性率明显增至100%，治疗4个月后降至25%。
