Cui J, Wang Z Q, Wu F, Jin X X
Department of Parasitology, Henan Medical University, Zhengzhou, China.
Ann Trop Med Parasitol. 1997 Jul;91(5):481-8. doi: 10.1080/00034989760842.
An outbreak of trichinosis occurred in the city of Zhengzhou, central China, between December 1995 and February 1996, affecting 85 of the administrative units into which the city is split. Of 297 subjects from eight of the affected units, 54% were seropositive for Trichinella and 41% had symptoms consistent with acute trichinosis. Of the 490 subjects who had eaten at one particular dumpling restaurant 1-5 weeks before the outbreak and who were traced, 291 (59%) were seropositive and 212 (43%) had been or were ill. MOst of the infections were in manual workers, cadres and merchants aged 20-49 years. Most of those who had been infected failed to develop gastro-intestinal symptoms or a cutaneous rash. Eyelid oedema was only seen in the early stages of the infection, the main clinical manifestations being fever of long duration of tiredness. Surprisingly, six cases had no marked symptoms after repeated infection. Eosinophilia (eosinophils > 7% of leucocytes) was noted in 71 (55%) of the 130 cases in which blood cells were counted. When 212 sera were tested for antibodies to Trichinella, seropositivities were found to increase from 89.1% (IFAT) of 87.7% (microprecipitation test) at presentation to 100% (both tests) 1 week after treatment with albendazole. All those treated were cured. The outbreak was one of the most extensive, single-source outbreaks ever recorded in China, probably with > 600 infections and > 300 clinical cases. The entire episode was attributed to the ingestion of undercooked pork dumplings at one restaurant.
1995年12月至1996年2月间，中国中部郑州市爆发了旋毛虫病，该市划分的85个行政单位受到影响。在来自8个受影响单位的297名受试者中，54%旋毛虫血清学呈阳性，41%有与急性旋毛虫病相符的症状。在疫情爆发前1 - 5周曾在一家特定饺子馆就餐且被追踪到的490名受试者中，291人（59%）血清学呈阳性，212人（43%）曾患病或正在患病。大多数感染者为20 - 49岁的体力劳动者、干部和商人。大多数感染者未出现胃肠道症状或皮疹。眼睑水肿仅在感染初期出现，主要临床表现为持续发热和疲劳。令人惊讶的是，6例患者在反复感染后无明显症状。在130例进行血细胞计数的病例中，71例（55%）出现嗜酸性粒细胞增多（嗜酸性粒细胞>白细胞的7%）。对212份血清进行旋毛虫抗体检测时，发现血清阳性率在服用阿苯达唑治疗1周后从初诊时的间接荧光抗体试验（IFAT）89.1%、微量沉淀试验87.7%升至两种检测均为100%。所有接受治疗的患者均治愈。此次疫情是中国有记录以来最广泛的单一来源疫情之一，可能有超过600例感染和超过300例临床病例。整个疫情归因于在一家餐馆食用了未煮熟的猪肉饺子。
