Waner T, Strenger C, Keysary A, Harrus S
Israel Institute for Biological Research, Ness Ziona.
Vet Immunol Immunopathol. 1998 Dec 11;66(3-4):237-43. doi: 10.1016/s0165-2427(98)00198-6.
The serological cross-reactions between the Ehrlichia canis and Ehrlichia phagocytophila genogroups, and the kinetics of development of antibodies in dogs to the E. phagocytophila group after artificial infection with the Israeli strain of E. canis was investigated. Results of this study indicate that the development of antibodies to the E. phagocytophila genogroup in dogs after infection with E. canis is a time dependent event probably conditional on the continued propagation of the rickettsia in the host. After spontaneous clinical recovery, and at the beginning of the subclinical phase, no antibodies to E. phagocytophila were yet detectable. The first evidence of IgG antibodies to E. phagocytophila were found in two of the six dogs, 55 days after artificial infection with E. canis, while another two dogs became seropositive to E. phagocytophila 22 days later. All surviving dogs were seropositive to E. phagocytophila by 150 days PI. It is suggested that the appearance of E. phagocytophila antibodies following treatment of acute E. canis infection may be used to judge treatment failure and/or persistence of infection.
研究了犬埃立克体（Ehrlichia canis）与嗜吞噬细胞埃立克体（Ehrlichia phagocytophila）基因组之间的血清学交叉反应，以及犬人工感染以色列株犬埃立克体后对嗜吞噬细胞埃立克体组抗体的产生动力学。本研究结果表明，犬感染犬埃立克体后对嗜吞噬细胞埃立克体基因组抗体的产生是一个时间依赖性事件，可能取决于立克次体在宿主体内的持续繁殖。自发临床恢复后以及亚临床阶段开始时，尚未检测到针对嗜吞噬细胞埃立克体的抗体。在人工感染犬埃立克体55天后，六只犬中有两只首次出现针对嗜吞噬细胞埃立克体的IgG抗体证据，另外两只犬在22天后对嗜吞噬细胞埃立克体血清学呈阳性。所有存活犬在感染后150天时对嗜吞噬细胞埃立克体血清学均呈阳性。有人提出，急性犬埃立克体感染治疗后嗜吞噬细胞埃立克体抗体的出现可用于判断治疗失败和/或感染持续存在。
