Hyett J, Perdu M, Sharland G, Snijders R, Nicolaides K H
Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College Hospital Medical School, London SE5 8RX.
BMJ. 1999 Jan 9;318(7176):81-5. doi: 10.1136/bmj.318.7176.81.
To examine the utility of measuring fetal nuchal translucency thickness in screening for major defects of the heart and great arteries at 10-14 weeks of gestation.
Population based cohort study.
29 154 singleton pregnancies with chromosomally normal fetuses at 10-14 weeks of gestation.
Fetal medicine centre in London.
Prevalence of major defects of the heart and great arteries.
Of 50 cases with major defects of the heart and great arteries (prevalence 1.7 per 1000 pregnancies) 28 (56%, 95% confidence interval 42% to 70%) were in the subgroup of 1822 pregnancies with fetal nuchal translucency thicknesses above the 95th centile of the normal range. The positive and negative predictive values for this cut off point of nuchal translucency thickness were 1.5% and 99.9% respectively.
Measurement of fetal nuchal translucency thickness-traditionally used to identify fetuses at high risk of aneuploidy-at 10-14 weeks of gestation can identify a large proportion of fetuses with major defects of the heart and great arteries.
探讨在妊娠10 - 14周时测量胎儿颈部透明带厚度在筛查心脏和大动脉主要缺陷中的作用。
基于人群的队列研究。
29154例妊娠10 - 14周、胎儿染色体正常的单胎妊娠。
伦敦的胎儿医学中心。
心脏和大动脉主要缺陷的患病率。
在50例心脏和大动脉主要缺陷病例（患病率为每1000例妊娠1.7例）中，28例（56%，95%置信区间42%至70%）在1822例胎儿颈部透明带厚度高于正常范围第95百分位数的妊娠亚组中。该颈部透明带厚度切点的阳性预测值和阴性预测值分别为1.5%和99.9%。
在妊娠10 - 14周时测量胎儿颈部透明带厚度——传统上用于识别非整倍体高风险胎儿——可识别出很大比例的心脏和大动脉主要缺陷胎儿。
