Sampson H W
Department of Human Anatomy and Neurobiology, College of Medicine, Texas A&M University, Health Science Center, College Station 77843-1114, USA.
Alcohol Clin Exp Res. 1998 Dec;22(9):2029-34.
The adult and aged skeleton exist in a time when osteoporosis and age-related bone loss is at a maximum, and it is modified by lifestyle factors such as alcohol. To determine the effect of life-long alcohol consumption on the adult and aged rat model, 4-week-old female Sprague-Dawley rats were divided into three diet groups. Alcohol-treated animals were fed a modified Lieber-DeCarli diet ad libitum containing 35% ethanol-derived calories, whereas the pair-fed animals (weight-matched to ethanol rats) received an isocaloric liquid diet in which maltose-dextrin substituted calories supplied by ethanol. Chow animals were fed a standard rat chow ad libitum. Proximal tibiae were removed and prepared for histomorphometric analysis after 3, 6, 9, 12, or 18 months on the diets. Previous studies, with young animals, showed that chronic alcohol consumption during the age of bone development reduced bone volume and trabecular number in cancellous bone. The present study demonstrates that these reductions last throughout life. The rate of bone formation is reduced in alcohol-fed animals, but most bone cell parameters are relative normal, except for wall thickness, indicating a reduced osteoblast activity.
成年和老年骨骼所处的时期，骨质疏松症和与年龄相关的骨质流失最为严重，且会受到酒精等生活方式因素的影响。为了确定终生饮酒对成年和老年大鼠模型的影响，将4周龄的雌性斯普拉格-道利大鼠分为三个饮食组。给予酒精处理的动物随意进食改良的利伯-德卡里饮食，其中35%的热量来自乙醇，而配对喂养的动物（体重与乙醇喂养的大鼠匹配）接受等热量的液体饮食，其中麦芽糖糊精替代了乙醇提供的热量。给予普通饮食的动物随意进食标准大鼠饲料。在饮食3、6、9、12或18个月后，取出近端胫骨并进行组织形态计量学分析。先前对幼龄动物的研究表明，在骨骼发育时期长期饮酒会减少松质骨的骨体积和小梁数量。本研究表明，这些减少会持续一生。酒精喂养的动物骨形成率降低，但除了骨壁厚度外，大多数骨细胞参数相对正常，这表明成骨细胞活性降低。
