Cekiç O, Batman C, Yasar U, Basci N E, Bozkurt A, Kayaalp S O
Department of Vitreoretinal Surgery, SSK Ankara Eye Hospital, Turkey.
Can J Ophthalmol. 1998 Dec;33(7):373-6.
Two ophthalmic solutions of 0.3% ciprofloxacin eyedrops are available in Turkey: Ciloxan and Siprogut. The objective of this study was to compare the concentrations of drug produced by the two products in the aqueous humour and vitreous humour after local administration.
Twenty-one patients undergoing primary vitreoretinal surgery received either Ciloxan (10 patients) or Siprogut (11 patients). Six hours before surgery, two drops of solution were instilled onto the operative eye. Drops were then instilled every 30 minutes for the first 3 hours and then hourly for the next 3 hours. Aqueous and vitreous samples were collected 30 minutes after administration of the last dose and were assayed for ciprofloxacin concentration by means of high-performance liquid chromatography with fluorometric detection.
The mean aqueous humour concentrations of Ciloxan and Siprogut were 0.36 (standard error of the mean [SEM] 0.09) microgram/mL and 0.44 (SEM 0.17) microgram/mL respectively. The corresponding vitreous humour concentrations were 0.21 (SEM 0.05) microgram/mL and 0.22 (SEM 0.06) microgram/mL. Neither of these differences was statistically significant. The aqueous and vitreous levels of both products exceeded the minimum inhibitory concentrations for certain bacterial species that frequently cause intraocular infections.
Our results show that the ocular bioavailability of Ciloxan and Siprogut after local administration is equivalent. Penetration of ciprofloxacin into the vitreous humour seems to be poorer than that into the aqueous humour.
在土耳其有两种0.3%的环丙沙星眼药水可供使用：Ciloxan和Siprogut。本研究的目的是比较局部给药后这两种产品在房水和玻璃体液中产生的药物浓度。
21例接受原发性玻璃体视网膜手术的患者分别使用Ciloxan（10例）或Siprogut（11例）。手术前6小时，将两滴溶液滴入手术眼。然后在前3小时每30分钟滴一次，接下来的3小时每小时滴一次。在最后一剂给药后30分钟收集房水和玻璃体液样本，并通过荧光检测的高效液相色谱法测定环丙沙星浓度。
Ciloxan和Siprogut的平均房水浓度分别为0.36（平均标准误差[SEM]0.09）微克/毫升和0.44（SEM 0.17）微克/毫升。相应的玻璃体液浓度分别为0.21（SEM 0.05）微克/毫升和0.22（SEM 0.06）微克/毫升。这些差异均无统计学意义。两种产品的房水和玻璃体液水平均超过了某些常见引起眼内感染的细菌种类的最低抑菌浓度。
我们的结果表明，局部给药后Ciloxan和Siprogut的眼内生物利用度相当。环丙沙星渗入玻璃体液的能力似乎比渗入房水的能力差。
